N-<2-<2-(Hydroxymethyl-4,5-dimethoxy-1-naphthyl)-3,5-dimethoxyphenyl>-1-methylethyl>acetamide

Base Information

• Chemical Name: N-<2-<2-(Hydroxymethyl-4,5-dimethoxy-1-naphthyl)-3,5-dimethoxyphenyl>-1-methylethyl>acetamide
• CAS No.: 123796-67-8
• Molecular Formula: C₂₆H₃₁NO₆
• Molecular Weight: 453.535
• Mol file: 123796-67-8.mol

Synonyms:N-<2-<2-(Hydroxymethyl-4,5-dimethoxy-1-naphthyl)-3,5-dimethoxyphenyl>-1-methylethyl>acetamide

Chemical Property of N-<2-<2-(Hydroxymethyl-4,5-dimethoxy-1-naphthyl)-3,5-dimethoxyphenyl>-1-methylethyl>acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<2-<2-(Hydroxymethyl-4,5-dimethoxy-1-naphthyl)-3,5-dimethoxyphenyl>-1-methylethyl>acetamide

There total 15 articles about N-<2-<2-(Hydroxymethyl-4,5-dimethoxy-1-naphthyl)-3,5-dimethoxyphenyl>-1-methylethyl>acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

Acetic acid 1-[4-(2-acetylamino-propyl)-2,6-dimethoxy-phenyl]-4,5-dimethoxy-naphthalen-2-ylmethyl ester (123796-66-7) → N-<2-<2-(Hydroxymethyl-4,5-dimethoxy-1-naphthyl)-3,5-dimethoxyphenyl>-1-methylethyl>acetamide (123796-67-8)

Guidance literature:

With sodium methylate; In methanol; for 1.5h; Ambient temperature;

DOI:10.1039/P19910000841

Reference yield:

1-<4-(2-Aminopropyl)-2,6-dimethoxyphenyl>-4,5-dimethoxy-2-naphthylmethanol (123796-65-6) → N-<2-<2-(Hydroxymethyl-4,5-dimethoxy-1-naphthyl)-3,5-dimethoxyphenyl>-1-methylethyl>acetamide (123796-67-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / pyridine / 2.5 h / 35 - 40 °C

2: 81 percent / NaOMe / methanol / 1.5 h / 25 °C

With sodium methylate; In pyridine; methanol;

DOI:10.1039/c39890000301

Reference yield:

Methyl 1-(4-Formyl-2,6-dimethoxyphenyl)-4,5-dimethoxynaphthalene-2-carboxylate (123796-63-4) → N-<2-<2-(Hydroxymethyl-4,5-dimethoxy-1-naphthyl)-3,5-dimethoxyphenyl>-1-methylethyl>acetamide (123796-67-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 80 percent / NH₄OAc / acetic acid / 1.5 h / 80 °C

2: 82 percent / LiAlH₄ / tetrahydrofuran / 2.5 h / Heating

3: 87 percent / pyridine / 2.5 h / 35 - 40 °C

4: 81 percent / NaOMe / methanol / 1.5 h / 25 °C

With lithium aluminium tetrahydride; ammonium acetate; sodium methylate; In tetrahydrofuran; pyridine; methanol; acetic acid;

DOI:10.1039/c39890000301

upstream raw materials:

Acetic acid 1-[4-(2-acetylamino-propyl)-2,6-dimethoxy-phenyl]-4,5-dimethoxy-naphthalen-2-ylmethyl ester

1-<4-(2-Aminopropyl)-2,6-dimethoxyphenyl>-4,5-dimethoxy-2-naphthylmethanol

Methyl 1-(4-Formyl-2,6-dimethoxyphenyl)-4,5-dimethoxynaphthalene-2-carboxylate

1-[2,6-Dimethoxy-4-((Z)-2-nitro-propenyl)-phenyl]-4,5-dimethoxy-naphthalene-2-carboxylic acid methyl ester

Downstream raw materials:

N-<2-<4-(4,5-Dimethoxy-2-methyl-1-naphthyl)-3,5-dimethoxyphenyl>-1-methylethyl>acetamide

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