methyl 2-(3,4-dimethoxyphenyl)-4-(1,3-dioxan-2-yl)-7-methoxybenzo[b]furan-3-carboxylate

Base Information

Chemical Name:methyl 2-(3,4-dimethoxyphenyl)-4-(1,3-dioxan-2-yl)-7-methoxybenzo[b]furan-3-carboxylate
CAS No.:1310802-08-4
Molecular Formula:C₂₃H₂₄O₈
Molecular Weight:428.439
Hs Code.:

Synonyms:methyl 2-(3,4-dimethoxyphenyl)-4-(1,3-dioxan-2-yl)-7-methoxybenzo[b]furan-3-carboxylate

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Chemical Property of methyl 2-(3,4-dimethoxyphenyl)-4-(1,3-dioxan-2-yl)-7-methoxybenzo[b]furan-3-carboxylate

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Technology Process of methyl 2-(3,4-dimethoxyphenyl)-4-(1,3-dioxan-2-yl)-7-methoxybenzo[b]furan-3-carboxylate

There total 8 articles about methyl 2-(3,4-dimethoxyphenyl)-4-(1,3-dioxan-2-yl)-7-methoxybenzo[b]furan-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 1310802-07-3
2-((3,4-dimethoxyphenyl)ethynyl)-3-(1,3-dioxan-2-yl)-6-methoxyphenol

: 1310802-08-4
methyl 2-(3,4-dimethoxyphenyl)-4-(1,3-dioxan-2-yl)-7-methoxybenzo[b]furan-3-carboxylate

Guidance literature:: With sodium acetate; copper dichloride; palladium dichloride; at 20 ℃; for 5h;
DOI:10.1021/ol201130h

Reference yield:

: 621-59-0
isovanillin

: 1310802-08-4
methyl 2-(3,4-dimethoxyphenyl)-4-(1,3-dioxan-2-yl)-7-methoxybenzo[b]furan-3-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine; Iodine monochloride / 1,4-dioxane / 144 h / 0 - 20 °C / Inert atmosphere; Darkness

2.1: pyridine / 16 h / 20 °C / Inert atmosphere; Darkness

3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diisopropylamine / ethyl acetate / 26 h / -20 - 20 °C / Inert atmosphere; Darkness

4.1: chloro-trimethyl-silane / dichloromethane / 2 h / Inert atmosphere; Reflux

5.1: methanol; caesium carbonate / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

5.2: 0 °C

6.1: sodium acetate; copper dichloride; palladium dichloride / 5 h / 20 °C

With pyridine; methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; chloro-trimethyl-silane; sodium acetate; Iodine monochloride; caesium carbonate; diisopropylamine; copper dichloride; palladium dichloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate; 3.1: Sonogashira coupling;
DOI:10.1021/ol201130h

Reference yield:

: 1310802-02-8
3-acetoxy-2-iodo-4-methoxybenzaldehyde

: 1310802-08-4
methyl 2-(3,4-dimethoxyphenyl)-4-(1,3-dioxan-2-yl)-7-methoxybenzo[b]furan-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diisopropylamine / ethyl acetate / 26 h / -20 - 20 °C / Inert atmosphere; Darkness

2.1: chloro-trimethyl-silane / dichloromethane / 2 h / Inert atmosphere; Reflux

3.1: methanol; caesium carbonate / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

3.2: 0 °C

4.1: sodium acetate; copper dichloride; palladium dichloride / 5 h / 20 °C

With methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; chloro-trimethyl-silane; sodium acetate; caesium carbonate; diisopropylamine; copper dichloride; palladium dichloride; In tetrahydrofuran; dichloromethane; ethyl acetate; 1.1: Sonogashira coupling;
DOI:10.1021/ol201130h