Technology Process of (R)-3-(4-chloro-3-methoxyphenyl)-1-(2,6-dimethylpyridin-4-yl)-6-methyl-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepine
There total 8 articles about (R)-3-(4-chloro-3-methoxyphenyl)-1-(2,6-dimethylpyridin-4-yl)-6-methyl-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydroxide / methanol; water / 2 h / 100 °C
1.2: 8 h / 20 °C
2.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,2-dimethoxyethane; water / 1 h / 150 °C / Microwave irradiation
With
tetrakis(triphenylphosphine) palladium(0); sodium carbonate; sodium hydroxide;
In
methanol; 1,2-dimethoxyethane; water;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: pyridinium p-toluenesulfonate / toluene / 7 h / Reflux
2.1: 20% palladium hydroxide-activated charcoal; hydrogen / methanol; water / 18 h / 40 °C
3.1: triethylsilane; trifluoroacetic acid / 3 h / 20 - 60 °C
4.1: dichloromethane / 18 h / 20 °C
5.1: tetrahydrofuran / 2 h / 150 °C / Microwave irradiation
5.2: 1 h / 100 °C
6.1: sodium hydroxide / methanol; water / 2 h / 100 °C
6.2: 8 h / 20 °C
7.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,2-dimethoxyethane; water / 1 h / 150 °C / Microwave irradiation
With
triethylsilane; tetrakis(triphenylphosphine) palladium(0); 20% palladium hydroxide-activated charcoal; hydrogen; pyridinium p-toluenesulfonate; sodium carbonate; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; toluene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 20% palladium hydroxide-activated charcoal; hydrogen / methanol; water / 18 h / 40 °C
2.1: triethylsilane; trifluoroacetic acid / 3 h / 20 - 60 °C
3.1: dichloromethane / 18 h / 20 °C
4.1: tetrahydrofuran / 2 h / 150 °C / Microwave irradiation
4.2: 1 h / 100 °C
5.1: sodium hydroxide / methanol; water / 2 h / 100 °C
5.2: 8 h / 20 °C
6.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,2-dimethoxyethane; water / 1 h / 150 °C / Microwave irradiation
With
triethylsilane; tetrakis(triphenylphosphine) palladium(0); 20% palladium hydroxide-activated charcoal; hydrogen; sodium carbonate; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water;