(R)-(4-(3-(4-chloro-3-methoxyphenyl)-6-methyl-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepin-1-yl)-6-methylpyridin-2-yl)methanol

Base Information

Chemical Name:(R)-(4-(3-(4-chloro-3-methoxyphenyl)-6-methyl-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepin-1-yl)-6-methylpyridin-2-yl)methanol
CAS No.:1623767-10-1
Molecular Formula:C₂₂H₂₄ClN₃O₃
Molecular Weight:413.904
Hs Code.:

Synonyms:(R)-(4-(3-(4-chloro-3-methoxyphenyl)-6-methyl-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepin-1-yl)-6-methylpyridin-2-yl)methanol

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Chemical Property of (R)-(4-(3-(4-chloro-3-methoxyphenyl)-6-methyl-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepin-1-yl)-6-methylpyridin-2-yl)methanol

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Technology Process of (R)-(4-(3-(4-chloro-3-methoxyphenyl)-6-methyl-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepin-1-yl)-6-methylpyridin-2-yl)methanol

There total 13 articles about (R)-(4-(3-(4-chloro-3-methoxyphenyl)-6-methyl-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepin-1-yl)-6-methylpyridin-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1623767-09-8
(R)-1-(2-(((tert-butyldimethylsilyl)oxy)methyl)-6-methylpyridin-4-yl)-3-(4-chloro-3-methoxyphenyl)-6-methyl-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepine

: 1623767-10-1
(R)-(4-(3-(4-chloro-3-methoxyphenyl)-6-methyl-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepin-1-yl)-6-methylpyridin-2-yl)methanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 1623767-11-2
(R)-4-(3-(4-chloro-3-methoxyphenyl)-6-methyl-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepin-1-yl)-2,6-dimethylpyridine 1-oxide

: 1623767-10-1
(R)-(4-(3-(4-chloro-3-methoxyphenyl)-6-methyl-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepin-1-yl)-6-methylpyridin-2-yl)methanol

Guidance literature:: (R)-4-(3-(4-chloro-3-methoxyphenyl)-6-methyl-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepin-1-yl)-2,6-dimethylpyridine 1-oxide; With acetic anhydride; at 100 ℃; for 3h;

With methanol; potassium carbonate; at 80 ℃; for 3h;

Reference yield:

: 1623766-30-2
(R)-N-(2,4-dimethoxybenzyl)-N-(2-hydroxypropyl)-3,3-dimethoxypropanamide

: 1623767-10-1
(R)-(4-(3-(4-chloro-3-methoxyphenyl)-6-methyl-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepin-1-yl)-6-methylpyridin-2-yl)methanol

Guidance literature:: Multi-step reaction with 9 steps

1.1: pyridinium p-toluenesulfonate / toluene / 7 h / Reflux

2.1: 20% palladium hydroxide-activated charcoal; hydrogen / methanol; water / 18 h / 40 °C

3.1: triethylsilane; trifluoroacetic acid / 3 h / 20 - 60 °C

4.1: dichloromethane / 18 h / 20 °C

5.1: tetrahydrofuran / 2 h / 150 °C / Microwave irradiation

5.2: 1 h / 100 °C

6.1: sodium hydroxide / methanol; water / 2 h / 100 °C

6.2: 8 h / 20 °C

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 1 h / 150 °C / Microwave irradiation

8.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 15 h / 20 °C

9.1: acetic anhydride / 3 h / 100 °C

9.2: 3 h / 80 °C

With triethylsilane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 20% palladium hydroxide-activated charcoal; hydrogen; pyridinium p-toluenesulfonate; acetic anhydride; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; toluene;