(R)-3-(4-chloro-3-methoxyphenyl)-1-(2-(fluoromethyl)-6-methylpyridin-4-yl)-6-methyl-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepine

Base Information

Chemical Name:(R)-3-(4-chloro-3-methoxyphenyl)-1-(2-(fluoromethyl)-6-methylpyridin-4-yl)-6-methyl-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepine
CAS No.:1623763-95-0
Molecular Formula:C₂₂H₂₃ClFN₃O₂
Molecular Weight:415.895
Hs Code.:

Synonyms:(R)-3-(4-chloro-3-methoxyphenyl)-1-(2-(fluoromethyl)-6-methylpyridin-4-yl)-6-methyl-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepine

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Chemical Property of (R)-3-(4-chloro-3-methoxyphenyl)-1-(2-(fluoromethyl)-6-methylpyridin-4-yl)-6-methyl-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepine

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Technology Process of (R)-3-(4-chloro-3-methoxyphenyl)-1-(2-(fluoromethyl)-6-methylpyridin-4-yl)-6-methyl-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepine

There total 14 articles about (R)-3-(4-chloro-3-methoxyphenyl)-1-(2-(fluoromethyl)-6-methylpyridin-4-yl)-6-methyl-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1623767-10-1
(R)-(4-(3-(4-chloro-3-methoxyphenyl)-6-methyl-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepin-1-yl)-6-methylpyridin-2-yl)methanol

: 1623763-95-0
(R)-3-(4-chloro-3-methoxyphenyl)-1-(2-(fluoromethyl)-6-methylpyridin-4-yl)-6-methyl-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepine

Guidance literature:: With (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane; at 20 ℃; for 13h;

Reference yield:

: 1623766-30-2
(R)-N-(2,4-dimethoxybenzyl)-N-(2-hydroxypropyl)-3,3-dimethoxypropanamide

: 1623763-95-0
(R)-3-(4-chloro-3-methoxyphenyl)-1-(2-(fluoromethyl)-6-methylpyridin-4-yl)-6-methyl-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepine

Guidance literature:: Multi-step reaction with 10 steps

1.1: pyridinium p-toluenesulfonate / toluene / 7 h / Reflux

2.1: 20% palladium hydroxide-activated charcoal; hydrogen / methanol; water / 18 h / 40 °C

3.1: triethylsilane; trifluoroacetic acid / 3 h / 20 - 60 °C

4.1: dichloromethane / 18 h / 20 °C

5.1: tetrahydrofuran / 2 h / 150 °C / Microwave irradiation

5.2: 1 h / 100 °C

6.1: sodium hydroxide / methanol; water / 2 h / 100 °C

6.2: 8 h / 20 °C

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 1 h / 150 °C / Microwave irradiation

8.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 15 h / 20 °C

9.1: acetic anhydride / 3 h / 100 °C

9.2: 3 h / 80 °C

10.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 13 h / 20 °C

With triethylsilane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 20% palladium hydroxide-activated charcoal; hydrogen; pyridinium p-toluenesulfonate; acetic anhydride; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; sodium hydroxide; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; toluene;

Reference yield:

: (R)-methyl 3-(4-chloro-3-methoxyphenyl)-6-methyl-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepine-1-carboxylate

: 1623763-95-0
(R)-3-(4-chloro-3-methoxyphenyl)-1-(2-(fluoromethyl)-6-methylpyridin-4-yl)-6-methyl-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / methanol; water / 2 h / 100 °C

1.2: 8 h / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 1 h / 150 °C / Microwave irradiation

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 15 h / 20 °C

4.1: acetic anhydride / 3 h / 100 °C

4.2: 3 h / 80 °C

5.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 13 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; acetic anhydride; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In methanol; 1,2-dimethoxyethane; dichloromethane; water;