5-chloro-N-(2,4-dimethoxybenzyl)-2,4-difluoro-N-(pyrimidin-2-yl)benzenesulfonamide

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Chemical Name:5-chloro-N-(2,4-dimethoxybenzyl)-2,4-difluoro-N-(pyrimidin-2-yl)benzenesulfonamide
CAS No.:1354786-64-3
Molecular Formula:C₁₉H₁₆ClF₂N₃O₄S
Molecular Weight:455.87
Hs Code.:

Synonyms:5-chloro-N-(2,4-dimethoxybenzyl)-2,4-difluoro-N-(pyrimidin-2-yl)benzenesulfonamide

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Chemical Property of 5-chloro-N-(2,4-dimethoxybenzyl)-2,4-difluoro-N-(pyrimidin-2-yl)benzenesulfonamide

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Technology Process of 5-chloro-N-(2,4-dimethoxybenzyl)-2,4-difluoro-N-(pyrimidin-2-yl)benzenesulfonamide

There total 2 articles about 5-chloro-N-(2,4-dimethoxybenzyl)-2,4-difluoro-N-(pyrimidin-2-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1275699-51-8
N-(2,4-dimethoxybenzyl)pyrimidin-2-amine

: 13656-57-0
5-chloro-2,4-difluorobenzene-1-sulfonyl chloride

: 1354786-64-3
5-chloro-N-(2,4-dimethoxybenzyl)-2,4-difluoro-N-(pyrimidin-2-yl)benzenesulfonamide

Guidance literature:: N-(2,4-dimethoxybenzyl)pyrimidin-2-amine; With lithium bis(trimethylsilyl)azanide; In tetrahydrofuran; at -78 - 0 ℃; for 0.5h;

5-chloro-2,4-difluorobenzene-1-sulfonyl chloride; In tetrahydrofuran; at -78 - 20 ℃; for 24.5h;

Reference yield:

: 20781-20-8
2,4-Dimethoxybenzylamine

: 1354786-64-3
5-chloro-N-(2,4-dimethoxybenzyl)-2,4-difluoro-N-(pyrimidin-2-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / ethanol / 0.25 h / 120 °C / Microwave irradiation

2.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 0 °C

2.2: 24.5 h / -78 - 20 °C

With triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol;