Technology Process of 5-bromo-N,N-diethyl-2-(2-fluoropyridin-3-yloxy)benzamide
There total 3 articles about 5-bromo-N,N-diethyl-2-(2-fluoropyridin-3-yloxy)benzamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5-bromo-2-(2-fluoropyridin-3-yloxy)benzoic acid; diethylamine;
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate;
In
N,N-dimethyl-formamide;
With
sodium hydrogencarbonate;
In
N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: caesium carbonate; copper(I) trifluoromethanesolfonate toluene complex / toluene / 2 h / 120 °C / Inert atmosphere
2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide
With
copper(I) trifluoromethanesolfonate toluene complex; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate;
In
N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: caesium carbonate; copper(I) trifluoromethanesolfonate toluene complex / toluene / 2 h / 120 °C / Inert atmosphere
2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide
With
copper(I) trifluoromethanesolfonate toluene complex; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate;
In
N,N-dimethyl-formamide; toluene;
