[5-(TERT-BUTYL)-2-HYDROXYPHENYL](PHENYL)METHANONE

Base Information

• Chemical Name: [5-(TERT-BUTYL)-2-HYDROXYPHENYL](PHENYL)METHANONE
• CAS No.: 10425-05-5
• Molecular Formula: C17H18 O2
• Molecular Weight: 254.329
• Hs Code.: 2914501900
• Mol file: 10425-05-5.mol

Synonyms:Benzophenone,5-tert-butyl-2-hydroxy- (7CI,8CI); 2-Hydroxy-5-tert-butylbenzophenone;5-tert-Butyl-2-hydroxybenzophenone

Chemical Property of [5-(TERT-BUTYL)-2-HYDROXYPHENYL](PHENYL)METHANONE

Chemical Property:

• Vapor Pressure: 5.16E-06mmHg at 25°C
• Melting Point: 67–68°C
• Boiling Point: 370.5°Cat760mmHg
• Flash Point: 158.1°C
• PSA: 37.30000
• Density: 1.093g/cm³
• LogP: 3.92070

Purity/Quality:

98%,99%, ^*data from raw suppliers

(5-tert-Butyl-2-hydroxyphenyl)(phenyl)methanone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [5-(TERT-BUTYL)-2-HYDROXYPHENYL](PHENYL)METHANONE

There total 22 articles about [5-(TERT-BUTYL)-2-HYDROXYPHENYL](PHENYL)METHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-(tert-butyl)-3-phenylbenzofuran-2(3H)-one (75846-32-1) → (5-(tert-butyl)-2-hydroxyphenyl)(phenyl)methanone (10425-05-5)

Guidance literature:

With tert.-butylhydroperoxide; sodium carbonate; nickel dichloride; In toluene; at 80 ℃; for 12h; Schlenk technique;

DOI:10.1021/acs.joc.0c00858

Reference yield: 77.0%

2-hydroxy-5-t-butylbenzaldehyde (2725-53-3) + phenylboronic acid (98-80-6) → (5-(tert-butyl)-2-hydroxyphenyl)(phenyl)methanone (10425-05-5)

Guidance literature:

With bis(benzonitrile)palladium(II) dichloride; oxygen; sodium hydrogencarbonate; copper dichloride; In N,N-dimethyl-formamide; at 80 ℃; for 14h;

DOI:10.1002/anie.201201502

Reference yield: 73.0%

para-tert-butylphenol (98-54-4) + benzonitrile (100-47-0) → (5-(tert-butyl)-2-hydroxyphenyl)(phenyl)methanone (10425-05-5)

Guidance literature:

With water; palladium diacetate; dimethyl sulfoxide; trifluoroacetic acid; In 1,2-dichloro-ethane; at 120 ℃; for 24h; regioselective reaction;

DOI:10.1016/j.tetlet.2017.09.062

upstream raw materials:

5-tert-butyl-2-methoxy-benzophenone

para-tert-butylphenol

Benzotrichlorid

4-tert-butylphenyl benzoate

Downstream raw materials:

3-acetyl-6-tert-butyl-4-phenyl-2H-chromen-2-one

5-(tert-butyl)-3-phenylbenzofuran

C₁₃H₉⁽¹⁸⁾FO₂

(5-fluoro-2-hydroxyphenyl)(phenyl)methanone

Refernces

• 1、 Siano, Gastón,Crespi, Stefano,Bonesi, Sergio M.. "Substituent and Surfactant Effects on the Photochemical Reaction of Some Aryl Benzoates in Micellar Green Environment?". . p. 1298 - 1309. Retrieved 2021/05/07.
• 2、 Chen, Chun-Jen,Chien, Chia-Chen,Kao, Shih-Chieh,Wu, Yen-Ku. "Photo-Fries rearrangement in flow under aqueous micellar conditions". supporting information. p. 15470 - 15472. Retrieved 2020/12/25.