tert-butyl N-[(2-{1,1-dimethyl-2-[methyl(phenyl)amino]-2-thioxoethyl}amino)-2-oxoethyl]carbamate

Base Information

Chemical Name:tert-butyl N-[(2-{1,1-dimethyl-2-[methyl(phenyl)amino]-2-thioxoethyl}amino)-2-oxoethyl]carbamate
CAS No.:457058-35-4
Molecular Formula:C₁₈H₂₇N₃O₃S
Molecular Weight:365.497
Hs Code.:

Synonyms:tert-butyl N-[(2-{1,1-dimethyl-2-[methyl(phenyl)amino]-2-thioxoethyl}amino)-2-oxoethyl]carbamate

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Chemical Property of tert-butyl N-[(2-{1,1-dimethyl-2-[methyl(phenyl)amino]-2-thioxoethyl}amino)-2-oxoethyl]carbamate

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Technology Process of tert-butyl N-[(2-{1,1-dimethyl-2-[methyl(phenyl)amino]-2-thioxoethyl}amino)-2-oxoethyl]carbamate

There total 1 articles about tert-butyl N-[(2-{1,1-dimethyl-2-[methyl(phenyl)amino]-2-thioxoethyl}amino)-2-oxoethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 4530-20-5
BOC-glycine

: 75755-40-7
2,2-dimethyl-3-(N-methyl-N-phenylamino)-2H-azirine

: 457058-35-4
tert-butyl N-[(2-{1,1-dimethyl-2-[methyl(phenyl)amino]-2-thioxoethyl}amino)-2-oxoethyl]carbamate

Guidance literature:: BOC-glycine; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -10 ℃; for 0.0833333h;

With hydrogen sulfide; In tetrahydrofuran; at -10 ℃; for 1h;

2,2-dimethyl-3-(N-methyl-N-phenylamino)-2H-azirine; In dichloromethane; at 0 - 20 ℃; for 4h;
DOI:10.1002/1522-2675(200204)85:4<990::AID-HLCA990>3.0.CO;2-6

Reference yield: 90.0%

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 457058-35-4
tert-butyl N-[(2-{1,1-dimethyl-2-[methyl(phenyl)amino]-2-thioxoethyl}amino)-2-oxoethyl]carbamate

: 457058-36-5
(9H-fluoren-9-yl)methyl N-[(2-{1,1-dimethyl-2-[methyl(phenyl)amino]-2-thioxoethyl}amino)-2-oxoethyl]carbamate

Guidance literature:: tert-butyl N-[(2-{1,1-dimethyl-2-[methyl(phenyl)amino]-2-thioxoethyl}amino)-2-oxoethyl]carbamate; With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 20h;

(fluorenylmethoxy)carbonyl chloride; With sodium hydrogencarbonate; In tetrahydrofuran; 1,4-dioxane; water; at 0 - 20 ℃; for 21h;
DOI:10.1002/1522-2675(200204)85:4<990::AID-HLCA990>3.0.CO;2-6

Reference yield:

: 457058-35-4
tert-butyl N-[(2-{1,1-dimethyl-2-[methyl(phenyl)amino]-2-thioxoethyl}amino)-2-oxoethyl]carbamate

: 457058-37-6
(9H-fluoren-9-yl)methyl N-[(2-{1,1-dimethyl-2-[methyl(phenyl)amino]-2-oxoethyl}amino)-2-thioxoethyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: HCl / tetrahydrofuran; H₂O / 20 h / 20 °C

1.2: 90 percent / NaHCO₃ / tetrahydrofuran; H₂O; dioxane / 21 h / 0 - 20 °C

2.1: ZnCl₂; AcOH / 0.33 h / 20 °C

2.2: 98 percent / HCl / acetic acid / 0.17 h / 20 °C

With hydrogenchloride; acetic acid; zinc(II) chloride; In tetrahydrofuran; water;
DOI:10.1002/1522-2675(200204)85:4<990::AID-HLCA990>3.0.CO;2-6