Technology Process of 2,2-Dimethyl-propionic acid 2-((4aS,5S,7S,8aR)-7-benzyloxymethyl-2,2,4a-trimethyl-hexahydro-1,6-dioxa-2-sila-naphthalen-5-yl)-ethyl ester
There total 12 articles about 2,2-Dimethyl-propionic acid 2-((4aS,5S,7S,8aR)-7-benzyloxymethyl-2,2,4a-trimethyl-hexahydro-1,6-dioxa-2-sila-naphthalen-5-yl)-ethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridine; dmap;
In
dichloromethane;
at 20 ℃;
for 8h;
DOI:10.1021/jo034930n
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: Me3Al / tetrahydrofuran / 0.5 h / 20 °C
1.2: 92 percent / tetrahydrofuran / -10 - 20 °C
2.1: Mg / tetrahydrofuran / 1 h
2.2: 62 percent / tetrahydrofuran / 2 h / 20 °C
3.1: 97 percent / Et3B; NaBH4 / tetrahydrofuran; methanol; hexane / 5 h / -78 °C
4.1: camphorsulfonic acid / CH2Cl2 / 1 h / 20 °C
5.1: 2.092 g / DIBAL / CH2Cl2; cyclohexane / 5 h / 20 °C
6.1: N-methylmorpholine / acetonitrile / 48 h
7.1: 0.516 g / DDQ / CH2Cl2; H2O / 1 h / 20 °C
8.1: Et3N; DMAP / benzene / 0.5 h / 20 °C
9.1: 4.143 g / n-Bu3SnH; AIBN / benzene / 5 h / Heating
10.1: LiBH4 / diethyl ether; tetrahydrofuran / 6 h / 20 °C
11.1: 4.233 g / pyridine; DMAP / CH2Cl2 / 8 h / 20 °C
With
4-methyl-morpholine; pyridine; dmap; sodium tetrahydroborate; lithium borohydride; 2,2'-azobis(isobutyronitrile); triethyl borane; camphor-10-sulfonic acid; trimethylaluminum; tri-n-butyl-tin hydride; diisobutylaluminium hydride; magnesium; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; cyclohexane; water; acetonitrile; benzene;
DOI:10.1021/jo034930n
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 97 percent / Et3B; NaBH4 / tetrahydrofuran; methanol; hexane / 5 h / -78 °C
2: camphorsulfonic acid / CH2Cl2 / 1 h / 20 °C
3: 2.092 g / DIBAL / CH2Cl2; cyclohexane / 5 h / 20 °C
4: N-methylmorpholine / acetonitrile / 48 h
5: 0.516 g / DDQ / CH2Cl2; H2O / 1 h / 20 °C
6: Et3N; DMAP / benzene / 0.5 h / 20 °C
7: 4.143 g / n-Bu3SnH; AIBN / benzene / 5 h / Heating
8: LiBH4 / diethyl ether; tetrahydrofuran / 6 h / 20 °C
9: 4.233 g / pyridine; DMAP / CH2Cl2 / 8 h / 20 °C
With
4-methyl-morpholine; pyridine; dmap; sodium tetrahydroborate; lithium borohydride; 2,2'-azobis(isobutyronitrile); triethyl borane; camphor-10-sulfonic acid; tri-n-butyl-tin hydride; diisobutylaluminium hydride; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; cyclohexane; water; acetonitrile; benzene;
DOI:10.1021/jo034930n
