(R)-1-phenylethanol picolinic acid ester

Base Information

• Chemical Name: (R)-1-phenylethanol picolinic acid ester
• CAS No.: 1073535-92-8
• Molecular Formula: C₁₄H₁₃NO₂
• Molecular Weight: 227.263
• Mol file: 1073535-92-8.mol

Synonyms:(R)-1-phenylethanol picolinic acid ester

Chemical Property of (R)-1-phenylethanol picolinic acid ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-phenylethanol picolinic acid ester

There total 1 articles about (R)-1-phenylethanol picolinic acid ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

2-Picolinic acid (98-98-6) + (S)-1-phenylethanol (1445-91-6) → (R)-1-phenylethanol picolinic acid ester (1073535-92-8)

Guidance literature:

With Vilsmeier reagent; triethylamine; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1080/00397910802109299

Reference yield:

(R)-1-phenylethanol picolinic acid ester (1073535-92-8) → (R)-1-phenylethanol (1517-69-7)

Guidance literature:

With methanol; (CH₃N₂C₃H₂CHNC₆H₁₀NHSO₂C₆H₄CH₃)ZnCl₂; sodium methylate; In d⁽⁴⁾-methanol; dichloromethane-d2; [D₃]acetonitrile; Kinetics;

DOI:10.1016/j.molcata.2011.02.014

Reference yield:

d(4)-methanol (811-98-3) + (R)-1-phenylethanol picolinic acid ester (1073535-92-8) → methyl-d3 picolinate (1429868-25-6) + C8H9(2)HO (1246182-86-4)

Guidance literature:

With C₂₄H₃₆F₃N₆O₅S⁽⁶⁴⁾Zn⁽¹⁺⁾*CF₃O₃S^(1-); In dichloromethane-d2; at 18.84 ℃; for 0.5h; Reagent/catalyst; enantioselective reaction; Kinetics;

DOI:10.1021/co3001023

upstream raw materials:

2-Picolinic acid

(S)-1-phenylethanol

Downstream raw materials:

(R)-1-phenylethanol

methyl-d₃ picolinate

C₈H₉⁽²⁾HO