4'-({4-[4-(cyclopropylcarbonyl)piperidin-1-yl]-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl}carbonyl)-3-fluorobiphenyl-2-carbonitrile

Base Information

Chemical Name:4'-({4-[4-(cyclopropylcarbonyl)piperidin-1-yl]-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl}carbonyl)-3-fluorobiphenyl-2-carbonitrile
CAS No.:1332453-13-0
Molecular Formula:C₃₀H₂₈FN₅O₂
Molecular Weight:509.583
Hs Code.:

Synonyms:4'-({4-[4-(cyclopropylcarbonyl)piperidin-1-yl]-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl}carbonyl)-3-fluorobiphenyl-2-carbonitrile

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Chemical Property of 4'-({4-[4-(cyclopropylcarbonyl)piperidin-1-yl]-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl}carbonyl)-3-fluorobiphenyl-2-carbonitrile

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Technology Process of 4'-({4-[4-(cyclopropylcarbonyl)piperidin-1-yl]-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl}carbonyl)-3-fluorobiphenyl-2-carbonitrile

There total 11 articles about 4'-({4-[4-(cyclopropylcarbonyl)piperidin-1-yl]-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl}carbonyl)-3-fluorobiphenyl-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 765916-91-4
2-fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

: 1332454-53-1
C₂₃H₂₅BrN₄O₂

: 1332453-13-0
4'-({4-[4-(cyclopropylcarbonyl)piperidin-1-yl]-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl}carbonyl)-3-fluorobiphenyl-2-carbonitrile

Guidance literature:: With caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; toluene; at 80 ℃; Inert atmosphere;

Reference yield:

: 1454-53-1
ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride

: 1332453-13-0
4'-({4-[4-(cyclopropylcarbonyl)piperidin-1-yl]-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl}carbonyl)-3-fluorobiphenyl-2-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: sodium alcoholate / ethanol / 2 h / Reflux

2: trichlorophosphate / N,N-dimethyl-formamide / acetonitrile / 3 h / Reflux

3: N-ethyl-N,N-diisopropylamine / ethanol / 3 h / 80 °C

4: ammonium formate / palladium(II) hydroxide / methanol / 3 h / Reflux

5: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 18 - 25 °C

6: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene; 1,4-dioxane / 80 °C / Inert atmosphere

With ammonium formate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; caesium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium(II) hydroxide; N,N-dimethyl-formamide; In 1,4-dioxane; methanol; ethanol; dichloromethane; toluene; acetonitrile;

Reference yield:

: 109229-22-3
6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one

: 1332453-13-0
4'-({4-[4-(cyclopropylcarbonyl)piperidin-1-yl]-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl}carbonyl)-3-fluorobiphenyl-2-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: trichlorophosphate / N,N-dimethyl-formamide / acetonitrile / 3 h / Reflux

2: N-ethyl-N,N-diisopropylamine / ethanol / 3 h / 80 °C

3: ammonium formate / palladium(II) hydroxide / methanol / 3 h / Reflux

4: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 18 - 25 °C

5: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene; 1,4-dioxane / 80 °C / Inert atmosphere

With ammonium formate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; caesium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium(II) hydroxide; N,N-dimethyl-formamide; In 1,4-dioxane; methanol; ethanol; dichloromethane; toluene; acetonitrile;