methyl (7R)-7-({2-[(tert-butoxycarbonyl)amino]ethyl}amino)-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

Base Information

Chemical Name:methyl (7R)-7-({2-[(tert-butoxycarbonyl)amino]ethyl}amino)-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate
CAS No.:886041-65-2
Molecular Formula:C₃₂H₄₁N₃O₅
Molecular Weight:547.695
Hs Code.:

Synonyms:methyl (7R)-7-({2-[(tert-butoxycarbonyl)amino]ethyl}amino)-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

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Chemical Property of methyl (7R)-7-({2-[(tert-butoxycarbonyl)amino]ethyl}amino)-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

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Technology Process of methyl (7R)-7-({2-[(tert-butoxycarbonyl)amino]ethyl}amino)-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

There total 16 articles about methyl (7R)-7-({2-[(tert-butoxycarbonyl)amino]ethyl}amino)-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 886041-64-1
methyl (7R)-7-amino-14-cyclohexyl-7,8-dihydro-6H-indolo-[1,2-e][1,5]benzoxazocine-11-carboxylate

: 89711-08-0
N-(t-butoxycarbonyl)glycinal

: 886041-65-2
methyl (7R)-7-({2-[(tert-butoxycarbonyl)amino]ethyl}amino)-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

Guidance literature:: methyl (7R)-7-amino-14-cyclohexyl-7,8-dihydro-6H-indolo-[1,2-e][1,5]benzoxazocine-11-carboxylate; N-(t-butoxycarbonyl)glycinal; In orthoformic acid triethyl ester; at 20 ℃;

With sodium cyanoborohydride; In methanol; at 20 ℃; for 1h;

With sodium hydroxide; water; In methanol; for 0.0833333h;

Reference yield:

: C₃₂H₃₉N₃O₅

: 886041-65-2
methyl (7R)-7-({2-[(tert-butoxycarbonyl)amino]ethyl}amino)-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

Guidance literature:: With sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃; for 1h;
DOI:10.1021/jm1013105

Reference yield:

: 886041-53-8
3-cyclohexyl-2-{2-[(2S)-oxiran-2-ylmethoxy]phenyl}-1H-indole-6-carboxylic acid methyl ester

: 886041-65-2
methyl (7R)-7-({2-[(tert-butoxycarbonyl)amino]ethyl}amino)-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: caesium carbonate / 1,4-dioxane / 48 h / Reflux

2: pyridine / 20 °C

3: trimethylsilylazide; tetrabutylammonium triphenyldifluorosilicate / tetrahydrofuran / 56 h / 65 °C

4: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 760.05 Torr

5: trimethyl orthoformate / 20 °C

6: sodium cyanoborohydride; acetic acid / methanol / 1 h / 20 °C

With pyridine; trimethylsilylazide; palladium 10% on activated carbon; hydrogen; sodium cyanoborohydride; caesium carbonate; acetic acid; tetrabutylammonium triphenyldifluorosilicate; trimethyl orthoformate; In tetrahydrofuran; 1,4-dioxane; methanol;
DOI:10.1021/jm1013105