methyl (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl)-amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

Base Information

Chemical Name:methyl (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl)-amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate
CAS No.:886041-66-3
Molecular Formula:C₃₀H₃₉N₃O₃
Molecular Weight:489.658
Hs Code.:

Synonyms:methyl (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl)-amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

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Chemical Property of methyl (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl)-amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

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Technology Process of methyl (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl)-amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

There total 8 articles about methyl (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl)-amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1267498-46-3
methyl (7R)-7-[(2-aminoethyl)amino]-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

: 886041-66-3
methyl (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl)-amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

Guidance literature:: formaldehyd; methyl (7R)-7-[(2-aminoethyl)amino]-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate; With palladium on activated charcoal; hydrogen; acetic acid; In methanol; at 28 ℃; for 15h; under 4137.29 Torr; Large scale reaction;

With sodium hydroxide; In methanol; water; at 23 ℃; for 15h; pH=14; Large scale reaction;
DOI:10.1021/op200002u

Reference yield: 80.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: C₂₈H₃₅N₃O₃*2ClH

: 886041-66-3
methyl (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl)-amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

Guidance literature:: formaldehyd; C₂₈H₃₅N₃O₃*2ClH; With sodium acetate; In methanol; water; at 20 ℃; for 0.166667h;

With palladium on carbon; hydrogen; In methanol; water; at 20 ℃; for 20h;
DOI:10.1055/s-0030-1260790

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 886041-65-2
methyl (7R)-7-({2-[(tert-butoxycarbonyl)amino]ethyl}amino)-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

: 886041-66-3
methyl (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl)-amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

Guidance literature:: methyl (7R)-7-({2-[(tert-butoxycarbonyl)amino]ethyl}amino)-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃;

formaldehyd; With sodium acetate; sodium cyanoborohydride; In dichloromethane; for 1h;

With sodium hydroxide; water; In dichloromethane; for 0.0833333h;