Technology Process of (R)-methyl 7-((2-aminoethyl)amino)-14-cyclohexyl-7,8-dihydro-6H-benzo[2,3][1,5]oxazocino[5,4-a]indole-11-carboxylate
There total 11 articles about (R)-methyl 7-((2-aminoethyl)amino)-14-cyclohexyl-7,8-dihydro-6H-benzo[2,3][1,5]oxazocino[5,4-a]indole-11-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
DOI:10.1021/jm1013105
- Guidance literature:
-
Multi-step reaction with 7 steps
1: caesium carbonate / 1,4-dioxane / 48 h / Reflux
2: pyridine / 20 °C
3: trimethylsilylazide; tetrabutylammonium triphenyldifluorosilicate / tetrahydrofuran / 56 h / 65 °C
4: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 760.05 Torr
5: trimethyl orthoformate / 20 °C
6: sodium cyanoborohydride; acetic acid / methanol / 1 h / 20 °C
7: trifluoroacetic acid / dichloromethane / 20 °C
With
pyridine; trimethylsilylazide; palladium 10% on activated carbon; hydrogen; sodium cyanoborohydride; caesium carbonate; acetic acid; tetrabutylammonium triphenyldifluorosilicate; trifluoroacetic acid; trimethyl orthoformate;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm1013105
- Guidance literature:
-
Multi-step reaction with 8 steps
1: cesium fluoride / N,N-dimethyl-formamide / 20 °C
2: caesium carbonate / 1,4-dioxane / 48 h / Reflux
3: pyridine / 20 °C
4: trimethylsilylazide; tetrabutylammonium triphenyldifluorosilicate / tetrahydrofuran / 56 h / 65 °C
5: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 760.05 Torr
6: trimethyl orthoformate / 20 °C
7: sodium cyanoborohydride; acetic acid / methanol / 1 h / 20 °C
8: trifluoroacetic acid / dichloromethane / 20 °C
With
pyridine; trimethylsilylazide; palladium 10% on activated carbon; hydrogen; sodium cyanoborohydride; caesium carbonate; acetic acid; cesium fluoride; tetrabutylammonium triphenyldifluorosilicate; trifluoroacetic acid; trimethyl orthoformate;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm1013105
