4,5-Bis(1,3,2-dithiarsolan-2-yl)-9-(4-fluorophenyl)-6-hydroxy-3H-xanthen-3-one

Base Information Edit

Chemical Name:4,5-Bis(1,3,2-dithiarsolan-2-yl)-9-(4-fluorophenyl)-6-hydroxy-3H-xanthen-3-one
CAS No.:1378318-62-7
Molecular Formula:C₂₃H₁₇As₂FO₃S₄
Molecular Weight:638.492
Hs Code.:
Mol file:1378318-62-7.mol

Synonyms:2,5-di-(1,3,2-dithiarsolan-2-yl)-9-(4-fluorophenyl)-6-hydroxy-3-fluorone

Suppliers and Price of 4,5-Bis(1,3,2-dithiarsolan-2-yl)-9-(4-fluorophenyl)-6-hydroxy-3H-xanthen-3-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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4,5-Bis(1,3,2-dithiarsolan-2-yl)-9-(4-fluorophenyl)-6-hydroxy-3H-xanthen-3-one
1mg
$ 195.00

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Chemical Property of 4,5-Bis(1,3,2-dithiarsolan-2-yl)-9-(4-fluorophenyl)-6-hydroxy-3H-xanthen-3-one Edit

Chemical Property:

Purity/Quality:: 4,5-Bis(1,3,2-dithiarsolan-2-yl)-9-(4-fluorophenyl)-6-hydroxy-3H-xanthen-3-one ^*data from reagent suppliers

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Useful:

Uses 4,5-Bis(1,3,2-dithiarsolan-2-yl)-9-(4-fluorophenyl)-6-hydroxy-3H-xanthen-3-one, is a new biarsenal ligands motifs used for fluorescent labeling of recombinant proteins in living cells.

Technology Process of 4,5-Bis(1,3,2-dithiarsolan-2-yl)-9-(4-fluorophenyl)-6-hydroxy-3H-xanthen-3-one

There total 6 articles about 4,5-Bis(1,3,2-dithiarsolan-2-yl)-9-(4-fluorophenyl)-6-hydroxy-3H-xanthen-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 9-(4-fluorophenyl)-6-hydroxy-3-fluorone-2,5-dimercuric trifluoroacetate

: 7784-34-1
arsenic trichloride

: 540-63-6
ethane-1,2-dithiol

: 1378318-62-7
2,5-di-(1,3,2-dithiarsolan-2-yl)-9-(4-fluorophenyl)-6-hydroxy-3-fluorone

Guidance literature:: 9-(4-fluorophenyl)-6-hydroxy-3-fluorone-2,5-dimercuric trifluoroacetate; arsenic trichloride; With N-ethyl-N,N-diisopropylamine; palladium diacetate; In 1-methyl-pyrrolidin-2-one; at 22 - 55 ℃; Inert atmosphere;

ethane-1,2-dithiol; In 1-methyl-pyrrolidin-2-one; acetone; for 0.5h; pH=6.9; Aqueous phosphate buffer;

Reference yield: 31.0%

: 9-(4-fluorophenyl)-6-hydroxy-3-fluorone-2,5-dimercuric trifluoroacetate

: 540-63-6
ethane-1,2-dithiol

: 1378318-62-7
2,5-di-(1,3,2-dithiarsolan-2-yl)-9-(4-fluorophenyl)-6-hydroxy-3-fluorone

Guidance literature:: 9-(4-fluorophenyl)-6-hydroxy-3-fluorone-2,5-dimercuric trifluoroacetate; With palladium diacetate; arsenic trichloride; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 550 ℃; for 2h; Inert atmosphere;

ethane-1,2-dithiol; With potassium dihydrogenphosphate; In 1-methyl-pyrrolidin-2-one; for 0.5h; pH=6.9;

Reference yield:

: 17715-69-4
1-Bromo-2,4-dimethoxybenzene

: 1378318-62-7
2,5-di-(1,3,2-dithiarsolan-2-yl)-9-(4-fluorophenyl)-6-hydroxy-3-fluorone

Guidance literature:: Multi-step reaction with 4 steps

1.1: iodine; magnesium / tetrahydrofuran / 0.5 h

2.1: boron tribromide / dichloromethane / -78 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine / palladium diacetate / 1-methyl-pyrrolidin-2-one / 22 - 55 °C / Inert atmosphere

4.2: 0.5 h / pH 6.9 / Aqueous phosphate buffer

With iodine; boron tribromide; magnesium; N-ethyl-N,N-diisopropylamine; palladium diacetate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane;