R62Tjm8EK3

Base Information

Chemical Name:R62Tjm8EK3
CAS No.:165115-74-2
Molecular Formula:C₂₁H₁₉F₂NO₃
Molecular Weight:371.384
Hs Code.:
UNII:R62TJM8EK3
Nikkaji Number:J760.537D

Synonyms:R62TJM8EK3;SCHEMBL3901913;2-Oxazolidinone, 3-[4-(2,4-difluorophenyl)-1-oxo-4-pentenyl]-4-(phenylmethyl)-, (R)-;3-[4-(2,4-Difluorophenyl)-1-oxo-4-penten-1-yl]-4-(phenylmethyl)-2-oxazolidinone, (R)-;165115-74-2

Suppliers and Price of R62Tjm8EK3

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 0 raw suppliers

Chemical Property of R62Tjm8EK3

Chemical Property:

XLogP3:4.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:371.13329979
Heavy Atom Count:27
Complexity:562

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C=C(CCC(=O)N1C(COC1=O)CC2=CC=CC=C2)C3=C(C=C(C=C3)F)F
Isomeric SMILES:C=C(CCC(=O)N1[C@@H](COC1=O)CC2=CC=CC=C2)C3=C(C=C(C=C3)F)F

Technology Process of R62Tjm8EK3

There total 7 articles about R62Tjm8EK3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40217-17-2,90719-32-7,120574-96-1,102029-44-7
(R)-4-(phenylmethyl)-2-oxazolidinone

: 165115-70-8
4-(2,4-difluorophenyl)-pent-4-enoic acid

: 165115-74-2
(R)-4-benzyl-3-(4-(2,4-difluorophenyl)pent-4-enoyl)oxazolidin-2-one

Guidance literature:: 4-(2,4-difluorophenyl)-pent-4-enoic acid; With pivaloyl chloride; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;

(R)-4-(phenylmethyl)-2-oxazolidinone; With dmap; N,N-dimethyl-formamide; In dichloromethane; at 45 - 50 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.ejmech.2018.11.056

Reference yield:

: 40217-17-2,90719-32-7,120574-96-1,102029-44-7
(R)-4-(phenylmethyl)-2-oxazolidinone

: 182009-37-6
4-(2,4-Difluoro-phenyl)-pent-4-enoyl chloride

: 165115-74-2
(R)-4-benzyl-3-(4-(2,4-difluorophenyl)pent-4-enoyl)oxazolidin-2-one

Guidance literature:: With dmap; In dichloromethane; N,N-dimethyl-formamide; at 20 - 50 ℃; for 4 - 5h;

Reference yield:

: 372-18-9
1,3-Difluorobenzene

: 165115-74-2
(R)-4-benzyl-3-(4-(2,4-difluorophenyl)pent-4-enoyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

2: tetrahydrofuran

4: tetrahydrofuran / -78 °C

In tetrahydrofuran;
DOI:10.1016/0040-4039(96)01203-8