[3S-[3alpha(S*),5alpha]]-3-[[5-(2,4-Difluorophenyl)tetrahydro-5-(iodomethyl)-3-furanyl]carbonyl]-4-(phenylmethyl)-2-oxazolidinone

Base Information

Chemical Name:[3S-[3alpha(S*),5alpha]]-3-[[5-(2,4-Difluorophenyl)tetrahydro-5-(iodomethyl)-3-furanyl]carbonyl]-4-(phenylmethyl)-2-oxazolidinone
CAS No.:165115-89-9
Molecular Formula:C22H20F2INO4
Molecular Weight:527.306
Hs Code.:

Synonyms:[3S-[3alpha(S*),5alpha]]-3-[[5-(2,4-Difluorophenyl)tetrahydro-5-(iodomethyl)-3-furanyl]carbonyl]-4-(phenylmethyl)-2-oxazolidinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [3S-[3alpha(S*),5alpha]]-3-[[5-(2,4-Difluorophenyl)tetrahydro-5-(iodomethyl)-3-furanyl]carbonyl]-4-(phenylmethyl)-2-oxazolidinone

Chemical Property:

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Technology Process of [3S-[3alpha(S*),5alpha]]-3-[[5-(2,4-Difluorophenyl)tetrahydro-5-(iodomethyl)-3-furanyl]carbonyl]-4-(phenylmethyl)-2-oxazolidinone

There total 6 articles about [3S-[3alpha(S*),5alpha]]-3-[[5-(2,4-Difluorophenyl)tetrahydro-5-(iodomethyl)-3-furanyl]carbonyl]-4-(phenylmethyl)-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 182009-45-6
(R)-4-benzyl-3-((S)-4-(2,4-difluorophenyl)-2-(hydroxymethyl)pent-4-enoyl)oxazolidin-2-one

: 165115-89-9
(R)-4-benzyl-3-((3S,5R)-5-(2,4-difluorophenyl)-5-(iodomethyl)tetrahydrofuran-3-carbonyl)oxazolidin-2-one

Guidance literature:: With pyridine; iodine; In acetonitrile; at 0 - 20 ℃; for 20h; Inert atmosphere;
DOI:10.1016/j.ejmech.2018.11.056

Reference yield:

: (-)-(4R)-4-benzyl-3-[4-(2,4-difluorophenyl)-2-hydroxymethyl-pent-4-enoyl]-oxazolidin-2-one

: 165115-89-9
(R)-4-benzyl-3-((3S,5R)-5-(2,4-difluorophenyl)-5-(iodomethyl)tetrahydrofuran-3-carbonyl)oxazolidin-2-one

Guidance literature:: With pyridine; iodine; In acetonitrile; at 0 - 20 ℃; for 6h;

Reference yield:

: 182009-45-6
(R)-4-benzyl-3-((S)-4-(2,4-difluorophenyl)-2-(hydroxymethyl)pent-4-enoyl)oxazolidin-2-one

: 165115-89-9
(R)-4-benzyl-3-((3S,5R)-5-(2,4-difluorophenyl)-5-(iodomethyl)tetrahydrofuran-3-carbonyl)oxazolidin-2-one

: (R)-4-Benzyl-3-[(3S,5S)-5-(2,4-difluoro-phenyl)-5-iodomethyl-tetrahydro-furan-3-carbonyl]-oxazolidin-2-one

Guidance literature:: With iodine; In pyridine; acetonitrile; for 20h; Yield given. Yields of byproduct given; Ambient temperature;
DOI:10.1016/0040-4039(96)01203-8