1-{4'-[3-methyl-4-(3-phenylpyrazol-1-ylmethyl)isoxazol-5-yl]biphenyl-4-yl}cyclopropanecarboxylic acid

Base Information

Chemical Name:1-{4'-[3-methyl-4-(3-phenylpyrazol-1-ylmethyl)isoxazol-5-yl]biphenyl-4-yl}cyclopropanecarboxylic acid
CAS No.:1280732-31-1
Molecular Formula:C₃₀H₂₅N₃O₃
Molecular Weight:475.547
Hs Code.:

Synonyms:1-{4'-[3-methyl-4-(3-phenylpyrazol-1-ylmethyl)isoxazol-5-yl]biphenyl-4-yl}cyclopropanecarboxylic acid

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Chemical Property of 1-{4'-[3-methyl-4-(3-phenylpyrazol-1-ylmethyl)isoxazol-5-yl]biphenyl-4-yl}cyclopropanecarboxylic acid

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Technology Process of 1-{4'-[3-methyl-4-(3-phenylpyrazol-1-ylmethyl)isoxazol-5-yl]biphenyl-4-yl}cyclopropanecarboxylic acid

There total 10 articles about 1-{4'-[3-methyl-4-(3-phenylpyrazol-1-ylmethyl)isoxazol-5-yl]biphenyl-4-yl}cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1280206-29-2
1-[4'-(4-bromomethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

: 2458-26-6
3-phenylpyrazole

: 1280732-31-1
1-{4'-[3-methyl-4-(3-phenylpyrazol-1-ylmethyl)isoxazol-5-yl]biphenyl-4-yl}cyclopropanecarboxylic acid

Guidance literature:: 1-[4'-(4-bromomethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester; 3-phenylpyrazole; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 1.5h;

With hydrogenchloride; In water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 345965-52-8
1-(4-bromophenyl)cyclopropanecarboxylic acid

: 1280732-31-1
1-{4'-[3-methyl-4-(3-phenylpyrazol-1-ylmethyl)isoxazol-5-yl]biphenyl-4-yl}cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / 1 h / 75 °C

2.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

3.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 60 - 80 °C / Inert atmosphere

4.1: phosphorus tribromide / 1,2-dimethoxyethane / 0 - 20 °C

4.2: 0 °C / pH 7

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.5 h / 20 °C

With sulfuric acid; potassium acetate; phosphorus tribromide; sodium hydride; sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; mineral oil; 3.1: Suzuki Coupling;

Reference yield:

: 85963-90-2
methyl 2-(4-bromobenzoyl)-3-oxo-butanoate

: 1280732-31-1
1-{4'-[3-methyl-4-(3-phenylpyrazol-1-ylmethyl)isoxazol-5-yl]biphenyl-4-yl}cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydroxylamine hydrochloride; acetic acid / 1 h / 115 °C

2.1: lithium borohydride; ethanol / 60 °C

3.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 60 - 80 °C / Inert atmosphere

4.1: phosphorus tribromide / 1,2-dimethoxyethane / 0 - 20 °C

4.2: 0 °C / pH 7

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.5 h / 20 °C

With lithium borohydride; ethanol; hydroxylamine hydrochloride; phosphorus tribromide; sodium hydride; sodium hydrogencarbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; mineral oil; 3.1: Suzuki Coupling;