1-(Benzyloxy)methyl-5-(methoxycarbonyl)-3-(methoxymethyl)-7-(p-nitrophenethyl)pyrrolo<2,3-d>pyrimidine-2,4-dione

Base Information

Chemical Name:1-(Benzyloxy)methyl-5-(methoxycarbonyl)-3-(methoxymethyl)-7-(p-nitrophenethyl)pyrrolo<2,3-d>pyrimidine-2,4-dione
CAS No.:165260-39-9
Molecular Formula:C₂₆H₂₆N₄O₈
Molecular Weight:522.514
Hs Code.:

Synonyms:1-(Benzyloxy)methyl-5-(methoxycarbonyl)-3-(methoxymethyl)-7-(p-nitrophenethyl)pyrrolo<2,3-d>pyrimidine-2,4-dione

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Chemical Property of 1-(Benzyloxy)methyl-5-(methoxycarbonyl)-3-(methoxymethyl)-7-(p-nitrophenethyl)pyrrolo<2,3-d>pyrimidine-2,4-dione

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Technology Process of 1-(Benzyloxy)methyl-5-(methoxycarbonyl)-3-(methoxymethyl)-7-(p-nitrophenethyl)pyrrolo<2,3-d>pyrimidine-2,4-dione

There total 1 articles about 1-(Benzyloxy)methyl-5-(methoxycarbonyl)-3-(methoxymethyl)-7-(p-nitrophenethyl)pyrrolo<2,3-d>pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 165260-38-8
1-(Benzyloxy)methyl-3-(methoxymethyl)-7-(p-nitrophenethyl)-5-(trifluoromethanesulfonyl)pyrrolo<2,3-d>pyrimidine-2,4-dione

: 165260-39-9
1-(Benzyloxy)methyl-5-(methoxycarbonyl)-3-(methoxymethyl)-7-(p-nitrophenethyl)pyrrolo<2,3-d>pyrimidine-2,4-dione

Guidance literature:: With triethylamine; triphenylphosphine; palladium diacetate; In N,N-dimethyl-formamide; at 70 - 72 ℃; for 4h;
DOI:10.1021/jo00121a027

Reference yield: 80.5%

: 165260-39-9
1-(Benzyloxy)methyl-5-(methoxycarbonyl)-3-(methoxymethyl)-7-(p-nitrophenethyl)pyrrolo<2,3-d>pyrimidine-2,4-dione

: 165260-40-2
1-(Benzyloxy)methyl-5-(methoxycarbonyl)-3-(methoxymethyl)pyrrolo<2,3-d>pyrimidine-2,4-dione

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; Ambient temperature;
DOI:10.1021/jo00121a027

Reference yield:

: 165260-39-9
1-(Benzyloxy)methyl-5-(methoxycarbonyl)-3-(methoxymethyl)-7-(p-nitrophenethyl)pyrrolo<2,3-d>pyrimidine-2,4-dione

: 161087-90-7
3-Methoxymethyl-7-[(2R,4S,5R)-4-(4-methyl-benzoyloxy)-5-(4-methyl-benzoyloxymethyl)-tetrahydro-furan-2-yl]-2,4-dioxo-2,3,4,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 80.5 percent / DBU / acetonitrile / Ambient temperature

2: NaH / acetonitrile / 1.) 45 deg C, 30 min, 2.) 1.5 h

3: H₂ / 20percent Pd(OH)2/C / methanol / 48 h / 25 °C

With hydrogen; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium dihydroxide; In methanol; acetonitrile;
DOI:10.1021/jo00121a027