4-[2-(9-Benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(tert-butyldimethylsilanyloxy)ethyl]cyclohexanone

Base Information

Chemical Name:4-[2-(9-Benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(tert-butyldimethylsilanyloxy)ethyl]cyclohexanone
CAS No.:1189555-53-0
Molecular Formula:C₃₁H₄₂N₂O₄SSi
Molecular Weight:566.837
Hs Code.:

Synonyms:4-[2-(9-Benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(tert-butyldimethylsilanyloxy)ethyl]cyclohexanone

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Chemical Property of 4-[2-(9-Benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(tert-butyldimethylsilanyloxy)ethyl]cyclohexanone

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Technology Process of 4-[2-(9-Benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(tert-butyldimethylsilanyloxy)ethyl]cyclohexanone

There total 8 articles about 4-[2-(9-Benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(tert-butyldimethylsilanyloxy)ethyl]cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1189555-51-8
4-[2-(9-Benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-hydroxyethyl]cyclohexanone

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1189555-53-0
4-[2-(9-Benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(tert-butyldimethylsilanyloxy)ethyl]cyclohexanone

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

Reference yield:

: 93245-98-8
1,4-dioxaspiro[4.5]decane-8-carbaldehyde

: 1189555-53-0
4-[2-(9-Benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(tert-butyldimethylsilanyloxy)ethyl]cyclohexanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.75 h / 20 °C

1.2: 18 h / 60 °C

2.1: calcium(II) trifluoromethanesulfonate / tetrahydrofuran / 48 h / 20 °C

3.1: hydrogenchloride; water / tetrahydrofuran / 16 h / 20 °C

4.1: 1H-imidazole / N,N-dimethyl-formamide / 48 h / 20 °C

With 1H-imidazole; hydrogenchloride; water; sodium hydride; calcium(II) trifluoromethanesulfonate; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 16502-01-5
tetrahydrobetacarboline

: 1189555-53-0
4-[2-(9-Benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(tert-butyldimethylsilanyloxy)ethyl]cyclohexanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: dmap / tetrahydrofuran / 16 h / 20 °C / Cooling with ice

2.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane / 1 h / 20 °C

2.2: 16 h / 20 °C / Cooling with ice

3.1: hydrogen bromide; acetic acid / 1 h / 20 °C

4.1: calcium(II) trifluoromethanesulfonate / tetrahydrofuran / 48 h / 20 °C

5.1: hydrogenchloride; water / tetrahydrofuran / 16 h / 20 °C

6.1: 1H-imidazole / N,N-dimethyl-formamide / 48 h / 20 °C

With 1H-imidazole; hydrogenchloride; dmap; water; hydrogen bromide; tetra(n-butyl)ammonium hydrogensulfate; calcium(II) trifluoromethanesulfonate; acetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;