4-[2-(9-Benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(tert-butyldimethylsilanyloxy)ethyl]-1-dimethylamino-cyclohexanecarbonitrile

Base Information

Chemical Name:4-[2-(9-Benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(tert-butyldimethylsilanyloxy)ethyl]-1-dimethylamino-cyclohexanecarbonitrile
CAS No.:1189555-54-1
Molecular Formula:C₃₄H₄₈N₄O₃SSi
Molecular Weight:620.932
Hs Code.:

4-[2-(9-Benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(tert-butyldimethylsilanyloxy)ethyl]-1-dimethylamino-cyclohexanecarbonitrile

Synonyms:4-[2-(9-Benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(tert-butyldimethylsilanyloxy)ethyl]-1-dimethylamino-cyclohexanecarbonitrile

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Chemical Property of 4-[2-(9-Benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(tert-butyldimethylsilanyloxy)ethyl]-1-dimethylamino-cyclohexanecarbonitrile

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Technology Process of 4-[2-(9-Benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(tert-butyldimethylsilanyloxy)ethyl]-1-dimethylamino-cyclohexanecarbonitrile

There total 9 articles about 4-[2-(9-Benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(tert-butyldimethylsilanyloxy)ethyl]-1-dimethylamino-cyclohexanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: potassium cyanide

: 1189555-53-0
4-[2-(9-Benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(tert-butyldimethylsilanyloxy)ethyl]cyclohexanone

: 124-40-3
dimethyl amine

: 1189555-54-1
4-[2-(9-Benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(tert-butyldimethylsilanyloxy)ethyl]-1-dimethylamino-cyclohexanecarbonitrile

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; methanol; water; at 20 ℃; Cooling with ice;

Reference yield:

: 93245-98-8
1,4-dioxaspiro[4.5]decane-8-carbaldehyde

: 1189555-54-1
4-[2-(9-Benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(tert-butyldimethylsilanyloxy)ethyl]-1-dimethylamino-cyclohexanecarbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.75 h / 20 °C

1.2: 18 h / 60 °C

2.1: calcium(II) trifluoromethanesulfonate / tetrahydrofuran / 48 h / 20 °C

3.1: hydrogenchloride; water / tetrahydrofuran / 16 h / 20 °C

4.1: 1H-imidazole / N,N-dimethyl-formamide / 48 h / 20 °C

5.1: hydrogenchloride / water; tetrahydrofuran; methanol / 20 °C / Cooling with ice

With 1H-imidazole; hydrogenchloride; water; sodium hydride; calcium(II) trifluoromethanesulfonate; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 16502-01-5
tetrahydrobetacarboline

: 1189555-54-1
4-[2-(9-Benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(tert-butyldimethylsilanyloxy)ethyl]-1-dimethylamino-cyclohexanecarbonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: dmap / tetrahydrofuran / 16 h / 20 °C / Cooling with ice

2.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane / 1 h / 20 °C

2.2: 16 h / 20 °C / Cooling with ice

3.1: hydrogen bromide; acetic acid / 1 h / 20 °C

4.1: calcium(II) trifluoromethanesulfonate / tetrahydrofuran / 48 h / 20 °C

5.1: hydrogenchloride; water / tetrahydrofuran / 16 h / 20 °C

6.1: 1H-imidazole / N,N-dimethyl-formamide / 48 h / 20 °C

7.1: hydrogenchloride / water; tetrahydrofuran; methanol / 20 °C / Cooling with ice

With 1H-imidazole; hydrogenchloride; dmap; water; hydrogen bromide; tetra(n-butyl)ammonium hydrogensulfate; calcium(II) trifluoromethanesulfonate; acetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;