[3-(2,6-Dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]methanol

Base Information

Chemical Name:[3-(2,6-Dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]methanol
CAS No.:175204-38-3
Molecular Formula:C11H9 Cl2 N O2
Molecular Weight:258.104
Hs Code.:2934999090
DSSTox Substance ID:DTXSID10381832
Wikidata:Q82172936
Mol file:175204-38-3.mol

Synonyms:175204-38-3;[3-(2,6-Dichlorophenyl)-5-methylisoxazol-4-yl]methanol;[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]methanol;(3-(2,6-Dichlorophenyl)-5-methylisoxazol-4-yl)methanol;3-(2,6-Dichlorophenyl)-4-(hydroxymethyl)-5-methylisoxazole;[3-[2,6-bis(chloranyl)phenyl]-5-methyl-1,2-oxazol-4-yl]methanol;Maybridge1_006052;SCHEMBL3451972;HMS558L02;DTXSID10381832;CCG-55636;MFCD00052550;AKOS015908610;PS-7388;CS-0316402;FT-0605411;H11090;SR-01000644653-1;A5Z

Suppliers and Price of [3-(2,6-Dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
3-(2,6-Dichlorophenyl)-4-(hydroxymethyl)-5-methylisoxazole
250 mg
$ 72.00

Crysdot
(3-(2,6-Dichlorophenyl)-5-methylisoxazol-4-yl)methanol 95+%
1g
$ 452.00

American Custom Chemicals Corporation
[3-(2,6-DICHLOROPHENYL)-5-METHYLISOXAZOL-4-YL]METHANOL 95.00%
1G
$ 810.35

Total 7 raw suppliers

Chemical Property of [3-(2,6-Dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]methanol

Chemical Property:

Vapor Pressure:4.62E-07mmHg at 25°C
Melting Point:107oC
Boiling Point:398.4oC at 760 mmHg
Flash Point:194.7oC
PSA：46.26000
Density:1.397g/cm3
LogP:3.44910
XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:257.0010339
Heavy Atom Count:16
Complexity:232

Purity/Quality:

98%min ^*data from raw suppliers

3-(2,6-Dichlorophenyl)-4-(hydroxymethyl)-5-methylisoxazole ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=NO1)C2=C(C=CC=C2Cl)Cl)CO

Technology Process of [3-(2,6-Dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]methanol

There total 6 articles about [3-(2,6-Dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 3919-76-4
3-(2,6-dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid

: 175204-38-3
[3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]methanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1016/j.bmcl.2006.05.055

Reference yield: 88.0%

: 4402-83-9
SPB 06193

: 175204-38-3
[3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]methanol

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 10h; Inert atmosphere;
DOI:10.1002/cmdc.201500136

Reference yield:

: 83-38-5
2,6-dichlorobenzaldehyde

: 175204-38-3
[3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]methanol

Guidance literature:: Multi-step reaction with 4 steps

1: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / 24 h / 90 °C

2: N-chloro-succinimide / N,N-dimethyl-formamide / 2 h / 20 °C

3: sodium methylate / tetrahydrofuran; methanol / 16 h / 20 °C

4: diisobutylaluminium hydride / tetrahydrofuran; toluene / 10 h / 0 - 20 °C / Inert atmosphere

With N-chloro-succinimide; hydroxylamine hydrochloride; sodium methylate; diisobutylaluminium hydride; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1002/cmdc.201500136