(S)-ethyl-5-(((S)-4-benzyloxazolidin-2-on-3-yl)carbonyl)-6-methyl-3-oxoheptanoate

Base Information

Chemical Name:(S)-ethyl-5-(((S)-4-benzyloxazolidin-2-on-3-yl)carbonyl)-6-methyl-3-oxoheptanoate
CAS No.:1351987-25-1
Molecular Formula:C₂₁H₂₇NO₆
Molecular Weight:389.448
Hs Code.:

Synonyms:(S)-ethyl-5-(((S)-4-benzyloxazolidin-2-on-3-yl)carbonyl)-6-methyl-3-oxoheptanoate

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Chemical Property of (S)-ethyl-5-(((S)-4-benzyloxazolidin-2-on-3-yl)carbonyl)-6-methyl-3-oxoheptanoate

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Technology Process of (S)-ethyl-5-(((S)-4-benzyloxazolidin-2-on-3-yl)carbonyl)-6-methyl-3-oxoheptanoate

There total 10 articles about (S)-ethyl-5-(((S)-4-benzyloxazolidin-2-on-3-yl)carbonyl)-6-methyl-3-oxoheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1351987-24-0
(S)-3-((S)-4-benzyloxazolidin-2-on-3-yl)-carbonyl-4-methyl pentanoic acid

: 6148-64-7
ethyl potassium malonate

: 1351987-25-1
(S)-ethyl-5-(((S)-4-benzyloxazolidin-2-on-3-yl)carbonyl)-6-methyl-3-oxoheptanoate

Guidance literature:: ethyl potassium malonate; With magnesium chloride; In tetrahydrofuran; for 12h; Reflux; Inert atmosphere;

(S)-3-((S)-4-benzyloxazolidin-2-on-3-yl)-carbonyl-4-methyl pentanoic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 - 22 ℃; for 3h;

With hydrogenchloride; In tetrahydrofuran; water; pH=2;

Reference yield:

: C₂₀H₂₃N₃O₄

: 6148-64-7
ethyl potassium malonate

: 1351987-25-1
(S)-ethyl-5-(((S)-4-benzyloxazolidin-2-on-3-yl)carbonyl)-6-methyl-3-oxoheptanoate

Guidance literature:: ethyl potassium malonate; With magnesium chloride; In tetrahydrofuran; for 12h; Inert atmosphere; Reflux;

C₂₀H₂₃N₃O₄; In tetrahydrofuran; at 20 - 22 ℃; for 3h;

Reference yield:

: 108-12-3
isopentanoyl chloride

: 1351987-25-1
(S)-ethyl-5-(((S)-4-benzyloxazolidin-2-on-3-yl)carbonyl)-6-methyl-3-oxoheptanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dmap / dichloromethane / 0.5 h / 0 - 10 °C

2.1: diisopropylamine; n-hexyllithium / hexane; tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere

2.2: 4 h / -78 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 20 °C

4.1: magnesium chloride / tetrahydrofuran / 12 h / Reflux; Inert atmosphere

4.2: 3 h / 20 - 22 °C

4.3: pH 2

With n-hexyllithium; triethylamine; diisopropylamine; trifluoroacetic acid; magnesium chloride; dmap; In tetrahydrofuran; hexane; dichloromethane;