Technology Process of (S)-ethyl-5-(((S)-4-benzyloxazolidin-2-on-3-yl)carbonyl)-6-methyl-3-oxoheptanoate
There total 10 articles about (S)-ethyl-5-(((S)-4-benzyloxazolidin-2-on-3-yl)carbonyl)-6-methyl-3-oxoheptanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
ethyl potassium malonate;
With
magnesium chloride;
In
tetrahydrofuran;
for 12h;
Reflux;
Inert atmosphere;
(S)-3-((S)-4-benzyloxazolidin-2-on-3-yl)-carbonyl-4-methyl pentanoic acid;
With
1,1'-carbonyldiimidazole;
In
tetrahydrofuran;
at 20 - 22 ℃;
for 3h;
With
hydrogenchloride;
In
tetrahydrofuran; water;
pH=2;
- Guidance literature:
-
ethyl potassium malonate;
With
magnesium chloride;
In
tetrahydrofuran;
for 12h;
Inert atmosphere;
Reflux;
C20H23N3O4;
In
tetrahydrofuran;
at 20 - 22 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine / dmap / dichloromethane / 0.5 h / 0 - 10 °C
2.1: diisopropylamine; n-hexyllithium / hexane; tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere
2.2: 4 h / -78 - 20 °C
3.1: trifluoroacetic acid / dichloromethane / 20 °C
4.1: magnesium chloride / tetrahydrofuran / 12 h / Reflux; Inert atmosphere
4.2: 3 h / 20 - 22 °C
4.3: pH 2
With
n-hexyllithium; triethylamine; diisopropylamine; trifluoroacetic acid; magnesium chloride;
dmap;
In
tetrahydrofuran; hexane; dichloromethane;
