(S)-ethyl 5-(((S)-4-benzyl-2-oxooxazolidin-3-yl)-carbonyl)-2-((R)-2-(4-methoxy-3-(3-methoxypropoxy)-benzyl)-3-methylbutylidene)-6-methyl-3-oxoheptanoate

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Chemical Name:(S)-ethyl 5-(((S)-4-benzyl-2-oxooxazolidin-3-yl)-carbonyl)-2-((R)-2-(4-methoxy-3-(3-methoxypropoxy)-benzyl)-3-methylbutylidene)-6-methyl-3-oxoheptanoate
CAS No.:1351987-29-5
Molecular Formula:C₃₈H₅₁NO₉
Molecular Weight:665.824
Hs Code.:

Synonyms:(S)-ethyl 5-(((S)-4-benzyl-2-oxooxazolidin-3-yl)-carbonyl)-2-((R)-2-(4-methoxy-3-(3-methoxypropoxy)-benzyl)-3-methylbutylidene)-6-methyl-3-oxoheptanoate

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Chemical Property of (S)-ethyl 5-(((S)-4-benzyl-2-oxooxazolidin-3-yl)-carbonyl)-2-((R)-2-(4-methoxy-3-(3-methoxypropoxy)-benzyl)-3-methylbutylidene)-6-methyl-3-oxoheptanoate

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Technology Process of (S)-ethyl 5-(((S)-4-benzyl-2-oxooxazolidin-3-yl)-carbonyl)-2-((R)-2-(4-methoxy-3-(3-methoxypropoxy)-benzyl)-3-methylbutylidene)-6-methyl-3-oxoheptanoate

There total 26 articles about (S)-ethyl 5-(((S)-4-benzyl-2-oxooxazolidin-3-yl)-carbonyl)-2-((R)-2-(4-methoxy-3-(3-methoxypropoxy)-benzyl)-3-methylbutylidene)-6-methyl-3-oxoheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 110-89-4
piperidine

: 1027979-11-8
(αR)-4-methoxy-3-(3-methoxypropoxy)-α-(1-methylethyl)benzenepropanal

: 1351987-25-1
(S)-ethyl-5-(((S)-4-benzyloxazolidin-2-on-3-yl)carbonyl)-6-methyl-3-oxoheptanoate

: 1351987-29-5
(S)-ethyl 5-(((S)-4-benzyl-2-oxooxazolidin-3-yl)-carbonyl)-2-((R)-2-(4-methoxy-3-(3-methoxypropoxy)-benzyl)-3-methylbutylidene)-6-methyl-3-oxoheptanoate

: (S)-ethyl 2-((R)-2-(4-methoxy-3-(3-methoxypropoxy)-benzyl)-3-methylbutylidene)-6-methyl-3-oxo-5-(piperidin-1-ylcarbonyl)heptanoate

Guidance literature:: In N,N-dimethyl-formamide; at 60 ℃; for 2h; Solvent; Reagent/catalyst; Inert atmosphere;
DOI:10.1021/acs.oprd.5b00396

Reference yield: 46.0%

: 1027979-11-8
(αR)-4-methoxy-3-(3-methoxypropoxy)-α-(1-methylethyl)benzenepropanal

: 1351987-25-1
(S)-ethyl-5-(((S)-4-benzyloxazolidin-2-on-3-yl)carbonyl)-6-methyl-3-oxoheptanoate

: 1351987-29-5
(S)-ethyl 5-(((S)-4-benzyl-2-oxooxazolidin-3-yl)-carbonyl)-2-((R)-2-(4-methoxy-3-(3-methoxypropoxy)-benzyl)-3-methylbutylidene)-6-methyl-3-oxoheptanoate

Guidance literature:: With pyridine; titanium tetrachloride; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;

Reference yield:

: 172900-75-3
4-methoxy-3-(3-methoxypropoxy)benzaldehyde

: 1351987-29-5
(S)-ethyl 5-(((S)-4-benzyl-2-oxooxazolidin-3-yl)-carbonyl)-2-((R)-2-(4-methoxy-3-(3-methoxypropoxy)-benzyl)-3-methylbutylidene)-6-methyl-3-oxoheptanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium diisopropyl amide / n-heptane; benzene; tetrahydrofuran / 1 h / -40 °C / Inert atmosphere

1.2: 2.25 h / -40 °C

2.1: camphor-10-sulfonic acid / toluene / Dean-Stark system; Reflux

3.1: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 20 °C / 760.05 Torr

4.1: hydrogenchloride; 2-amino-2-hydroxymethyl-1,3-propanediol; water; HLAP / 48 h / 40 °C / Enzymatic reaction

4.2: 20 °C / pH 3.5

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 40 °C / Inert atmosphere

5.2: 20 °C

6.1: potassium carbonate; tetrabutyl-ammonium chloride; sodium hydrogencarbonate / N-chloro-succinimide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; water / 3 h / 20 °C

7.1: pyridine; titanium tetrachloride / dichloromethane; tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; HLAP; tetrabutyl-ammonium chloride; water; hydrogen; titanium tetrachloride; sodium hydrogencarbonate; potassium carbonate; 2-amino-2-hydroxymethyl-1,3-propanediol; lithium diisopropyl amide; N-chloro-succinimide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; palladium 10% on activated carbon; camphor-10-sulfonic acid; In tetrahydrofuran; methanol; n-heptane; dichloromethane; water; toluene; benzene; 7.1: Knoevenagel Condensation;