2-[3-(1,3-dicarboxypropyl)ureido]pentanedioic acid-8-aminocaprylic acid-Phe-Phe-2, 3-diaminopropianic acid-Asp-Cys

Base Information

• Chemical Name: 2-[3-(1,3-dicarboxypropyl)ureido]pentanedioic acid-8-aminocaprylic acid-Phe-Phe-2, 3-diaminopropianic acid-Asp-Cys
• CAS No.: 1025066-50-5
• Molecular Formula: C₄₇H₆₅N₉O₁₇S
• Molecular Weight: 1060.15
• Mol file: 1025066-50-5.mol

Synonyms:2-[3-(1,3-dicarboxypropyl)ureido]pentanedioic acid-8-aminocaprylic acid-Phe-Phe-2, 3-diaminopropianic acid-Asp-Cys

Chemical Property of 2-[3-(1,3-dicarboxypropyl)ureido]pentanedioic acid-8-aminocaprylic acid-Phe-Phe-2, 3-diaminopropianic acid-Asp-Cys

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[3-(1,3-dicarboxypropyl)ureido]pentanedioic acid-8-aminocaprylic acid-Phe-Phe-2, 3-diaminopropianic acid-Asp-Cys

There total 6 articles about 2-[3-(1,3-dicarboxypropyl)ureido]pentanedioic acid-8-aminocaprylic acid-Phe-Phe-2, 3-diaminopropianic acid-Asp-Cys which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

(S)-5-(tert-butoxy)-4-(3-((S)-1,5-di-tert-butoxy-1,5-dioxopentan-2-yl)ureido)-5-oxopentanoic acid (1026987-94-9) + C45H38NO5PolS + N-Fmoc L-Phe (35661-40-6) + Fmoc-(tBu)Asp-OH (71989-14-5) + Boc-Dap(Fmoc)-OH (131570-56-4,122235-70-5,159002-16-1) + 8-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)octanoic acid (126631-93-4) → 2-[3-(1,3-dicarboxypropyl)ureido]pentanedioic acid-8-aminocaprylic acid-Phe-Phe-2, 3-diaminopropianic acid-Asp-Cys (1025066-50-5)

Guidance literature:

C₄₅H₃₈NO₅PolS; With piperidine; In N,N-dimethyl-formamide; Wang resin

Fmoc-(tBu)Asp-OH; With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; Wang resin

(S)-5-(tert-butoxy)-4-(3-((S)-1,5-di-tert-butoxy-1,5-dioxopentan-2-yl)ureido)-5-oxopentanoic acid; N-Fmoc L-Phe; Boc-Dap(Fmoc)-OH; 8-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)octanoic acid; Further stages;

Reference yield: 61.0%

fmoc-Cys(Trt)-Wang Resin + (S)-5-(tert-butoxy)-4-(3-((S)-1,5-di-tert-butoxy-1,5-dioxopentan-2-yl)ureido)-5-oxopentanoic acid (1026987-94-9) + N-Fmoc L-Phe (35661-40-6) + Fmoc-(tBu)Asp-OH (71989-14-5) + Boc-Dap(Fmoc)-OH (131570-56-4,122235-70-5,159002-16-1) + 8-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)octanoic acid (126631-93-4) → 2-[3-(1,3-dicarboxypropyl)ureido]pentanedioic acid-8-aminocaprylic acid-Phe-Phe-2, 3-diaminopropianic acid-Asp-Cys (1025066-50-5)

Guidance literature:

fmoc-Cys(Trt)-Wang Resin; With piperidine; In N,N-dimethyl-formamide; Wang resin

Fmoc-(tBu)Asp-OH; With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; Wang resin

(S)-5-(tert-butoxy)-4-(3-((S)-1,5-di-tert-butoxy-1,5-dioxopentan-2-yl)ureido)-5-oxopentanoic acid; N-Fmoc L-Phe; Boc-Dap(Fmoc)-OH; 8-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)octanoic acid; Further stages;

Reference yield: 58.0%

(S)-5-(tert-butoxy)-4-(3-((S)-1,5-di-tert-butoxy-1,5-dioxopentan-2-yl)ureido)-5-oxopentanoic acid (1026987-94-9) + C41H33ClNO2PolS + N-Fmoc L-Phe (35661-40-6) + Fmoc-(tBu)Asp-OH (71989-14-5) + Boc-Dap(Fmoc)-OH (131570-56-4,122235-70-5,159002-16-1) + 8-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)octanoic acid (126631-93-4) → 2-[3-(1,3-dicarboxypropyl)ureido]pentanedioic acid-8-aminocaprylic acid-Phe-Phe-2, 3-diaminopropianic acid-Asp-Cys (1025066-50-5)

Guidance literature:

C₄₁H₃₃ClNO₂PolS; Fmoc-(tBu)Asp-OH; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 3.5h; H-L-Cys(Trt)-(2-ClTrt) resin Inert atmosphere;

With piperidine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

(S)-5-(tert-butoxy)-4-(3-((S)-1,5-di-tert-butoxy-1,5-dioxopentan-2-yl)ureido)-5-oxopentanoic acid; N-Fmoc L-Phe; Boc-Dap(Fmoc)-OH; 8-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)octanoic acid; Further stages;

upstream raw materials:

(S)-5-(tert-butoxy)-4-(3-((S)-1,5-di-tert-butoxy-1,5-dioxopentan-2-yl)ureido)-5-oxopentanoic acid

N-Fmoc L-Phe

Fmoc-(tBu)Asp-OH

Boc-Dap(Fmoc)-OH

Downstream raw materials:

C₉₀H₁₁₉N₁₃O₃₀S₄