N-{2-[2-(3,4-dimethoxy-phenylethynyl)-4,5-dimethoxy-phenyl]-ethyl}-2,2,2-trifluoro-acetamide

Base Information

Chemical Name:N-{2-[2-(3,4-dimethoxy-phenylethynyl)-4,5-dimethoxy-phenyl]-ethyl}-2,2,2-trifluoro-acetamide
CAS No.:863132-19-8
Molecular Formula:C₂₂H₂₂F₃NO₅
Molecular Weight:437.416
Hs Code.:

<i>N</i>-{2-[2-(3,4-dimethoxy-phenylethynyl)-4,5-dimethoxy-phenyl]-ethyl}-2,2,2-trifluoro-acetamide

Synonyms:N-{2-[2-(3,4-dimethoxy-phenylethynyl)-4,5-dimethoxy-phenyl]-ethyl}-2,2,2-trifluoro-acetamide

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Chemical Property of N-{2-[2-(3,4-dimethoxy-phenylethynyl)-4,5-dimethoxy-phenyl]-ethyl}-2,2,2-trifluoro-acetamide

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Technology Process of N-{2-[2-(3,4-dimethoxy-phenylethynyl)-4,5-dimethoxy-phenyl]-ethyl}-2,2,2-trifluoro-acetamide

There total 6 articles about N-{2-[2-(3,4-dimethoxy-phenylethynyl)-4,5-dimethoxy-phenyl]-ethyl}-2,2,2-trifluoro-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-ethynylveratrole: 4302-52-7
4-ethynylveratrole

: 154138-43-9
2,2,2-trifluoro-N-<2-(2-iodo-4,5-dimethoxyphenyl)ethyl>acetamide

: 863132-19-8
N-{2-[2-(3,4-dimethoxy-phenylethynyl)-4,5-dimethoxy-phenyl]-ethyl}-2,2,2-trifluoro-acetamide

Guidance literature:: With copper(l) iodide; diisopropylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; at 25 ℃; for 16h;
DOI:10.1002/ejoc.200500095

Reference yield:

: 863132-17-6
(3,4-dimethoxy-phenylethynyl)-trimethyl-silane

: 863132-19-8
N-{2-[2-(3,4-dimethoxy-phenylethynyl)-4,5-dimethoxy-phenyl]-ethyl}-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / K₂CO₃ / methanol / 4 h / 25 °C

2: 84 percent / CuI; PPh₃; iPr₂NH / Pd(PPh₃)2Cl₂ / 16 h / 25 °C

With copper(l) iodide; potassium carbonate; diisopropylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; In methanol; 2: Sonogashira coupling reaction;
DOI:10.1002/ejoc.200500095

Reference yield:

: 91-16-7
1,2-dimethoxybenzene

: 863132-19-8
N-{2-[2-(3,4-dimethoxy-phenylethynyl)-4,5-dimethoxy-phenyl]-ethyl}-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / I₂; HIO₃ / methanol; H₂O / 48 h / 85 °C

2: 92 percent / CuI; PPh₃; iPr₂NH / Pd(PPh₃)2Cl₂ / 16.5 h / 25 °C

3: 82 percent / K₂CO₃ / methanol / 4 h / 25 °C

4: 84 percent / CuI; PPh₃; iPr₂NH / Pd(PPh₃)2Cl₂ / 16 h / 25 °C

With copper(l) iodide; iodine; iodic acid; potassium carbonate; diisopropylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; In methanol; water; 2: Sonogashira coupling reaction / 4: Sonogashira coupling reaction;
DOI:10.1002/ejoc.200500095