Technology Process of 2-(7-(benzyloxy)-3,3-diethyl-4-fluoroindolin-1-yl)aniline
There total 5 articles about 2-(7-(benzyloxy)-3,3-diethyl-4-fluoroindolin-1-yl)aniline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-nitrophenyl bromide; 7-(benzyloxy)-3,3-diethyl-4-fluoroindoline;
With
potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
toluene;
at 120 ℃;
for 66h;
Inert atmosphere;
Sealed tube;
With
ammonium chloride; zinc;
In
ethanol;
at 20 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C
1.2: 5 h / 20 °C
2.1: sodium nitrite; hydrogenchloride / water / 0.33 h / -10 - 0 °C
2.2: 0.33 h
3.1: sulfuric acid / ethanol / 48 h / 0 - 20 °C
3.2: 0.75 h / -10 - 20 °C
4.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium(0); potassium phosphate / toluene / 66 h / 120 °C / Inert atmosphere; Sealed tube
4.2: 3 h / 20 °C
With
hydrogenchloride; potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); sulfuric acid; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium nitrite;
In
ethanol; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C
1.2: 5 h / 20 °C
2.1: sodium nitrite; hydrogenchloride / water / 0.33 h / -10 - 0 °C
2.2: 0.33 h
3.1: sulfuric acid / ethanol / 48 h / 0 - 20 °C
3.2: 0.75 h / -10 - 20 °C
4.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium(0); potassium phosphate / toluene / 66 h / 120 °C / Inert atmosphere; Sealed tube
4.2: 3 h / 20 °C
With
hydrogenchloride; potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); sulfuric acid; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium nitrite;
In
ethanol; water; N,N-dimethyl-formamide; toluene;
