1-[5-methyl-2-(methylsulfanyl)phenyl]ethanone

Base Information

• Chemical Name: 1-[5-methyl-2-(methylsulfanyl)phenyl]ethanone
• CAS No.: 1964-27-8
• Molecular Formula: C10H12 O S
• Molecular Weight: 180.2667
• Mol file: 1964-27-8.mol

Synonyms:Acetophenone,5'-methyl-2'-(methylthio)- (7CI,8CI); Methyl 2-(methylthio)-5-methylphenylketone; NSC 329357

Chemical Property of 1-[5-methyl-2-(methylsulfanyl)phenyl]ethanone

Chemical Property:

• Vapor Pressure: 0.00521mmHg at 25°C
• Boiling Point: 275.1°Cat760mmHg
• Flash Point: 128.5°C
• Density: 1.08g/cm³

Purity/Quality:

90%,98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-[5-methyl-2-(methylsulfanyl)phenyl]ethanone

There total 5 articles about 1-[5-methyl-2-(methylsulfanyl)phenyl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methylphenyl methylsulfide (623-13-2) + acetyl chloride (75-36-5) → 1-(5-methyl-2-methylsulfanyl-phenyl)-ethanone (1964-27-8)

Guidance literature:

With aluminium trichloride; chloroform;

Reference yield:

para-thiocresol (106-45-6) → 1-(5-methyl-2-methylsulfanyl-phenyl)-ethanone (1964-27-8)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH-solution

2: AlCl₃; CS₂

With carbon disulfide; sodium hydroxide; aluminium trichloride;

Reference yield:

4-methylanthranilic acid (2305-36-4) → 1-(5-methyl-2-methylsulfanyl-phenyl)-ethanone (1964-27-8)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) (diazotization), (ii) aq. Na₂S₂, (iii) aq. Na₂S₂O₄,(iv) (methylation)

2: (i) SOCl₂, (ii) /BRN= 774687/, Mg, (iii) H₂SO₄, AcOH

upstream raw materials:

4-methylphenyl methylsulfide

acetyl chloride

4-methyl-2-methylsulfanyl-benzoic acid

diethyl malonate

Downstream raw materials:

N-[1-(5-Methyl-2-methylsulfanyl-phenyl)-eth-(Z)-ylidene]-N'-phenyl-hydrazine

1-(5-methyl-2-methylsulfanyl-phenyl)-ethanone oxime

2-Methylsulfinyl-5-methylbenzoesaeure

5-methyl-2-(methylsulphinyl)acetophenone