2-[4-((E)-2-cyanoethenesulfonyl)phenyl]-N-(2-methoxybenzyl)isobutyramide

Base Information

Chemical Name:2-[4-((E)-2-cyanoethenesulfonyl)phenyl]-N-(2-methoxybenzyl)isobutyramide
CAS No.:1394819-33-0
Molecular Formula:C₂₁H₂₂N₂O₄S
Molecular Weight:398.483
Hs Code.:

Synonyms:2-[4-((E)-2-cyanoethenesulfonyl)phenyl]-N-(2-methoxybenzyl)isobutyramide

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Chemical Property of 2-[4-((E)-2-cyanoethenesulfonyl)phenyl]-N-(2-methoxybenzyl)isobutyramide

Chemical Property:

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Technology Process of 2-[4-((E)-2-cyanoethenesulfonyl)phenyl]-N-(2-methoxybenzyl)isobutyramide

There total 3 articles about 2-[4-((E)-2-cyanoethenesulfonyl)phenyl]-N-(2-methoxybenzyl)isobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 6850-57-3
2-methoxybenzylamine

: 1356089-38-7
2-[4-((E)-2-cyano-ethenesulfonyl)phenyl]-2-methylpropionic acid

: 1394819-33-0
2-[4-((E)-2-cyanoethenesulfonyl)phenyl]-N-(2-methoxybenzyl)isobutyramide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 20 ℃; for 2h;

Reference yield:

: 32454-35-6
2-(4-bromophenyl)-2-methylpropionic acid

: 1394819-33-0
2-[4-((E)-2-cyanoethenesulfonyl)phenyl]-N-(2-methoxybenzyl)isobutyramide

Guidance literature:: Multi-step reaction with 3 steps

1.1: phenyllithium / toluene; tetrahydrofuran / 0.08 h / -80 °C / Inert atmosphere

1.2: 0.33 h

1.3: 0.25 h

2.1: acetic acid / water; methanol / 20 °C

2.2: 1 h

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 2 h / 20 °C

With benzotriazol-1-ol; acetic acid; phenyllithium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; water; toluene; acetonitrile;

Reference yield:

: C₁₀H₁₂O₄S

: 1394819-33-0
2-[4-((E)-2-cyanoethenesulfonyl)phenyl]-N-(2-methoxybenzyl)isobutyramide

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / methanol / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 2 h / 20 °C

With benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; acetonitrile;
DOI:10.1021/jm501437v