Multi-step reaction with 9 steps
1.1: potassium hexamethylsilazane / 1,4-dioxane / 22 h / 100 °C
2.1: 1 h / 80 °C
3.1: trichlorophosphate / 1.13 h / Cooling with ice
3.2: 1.5 h / 50 - 70 °C
4.1: sodium hydroxide; water / ethanol / 0.5 h / 20 °C
5.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C
6.1: phenyllithium / dibutyl ether; tetrahydrofuran / 0.25 h / Cooling with ice; Inert atmosphere
6.2: 2.13 h / Cooling with ice; Inert atmosphere
7.1: n-butyllithium / hexane; tetrahydrofuran / 0.58 h / -72 - -66 °C / Inert atmosphere
7.2: 1.5 h / -72 - -10 °C / Inert atmosphere
7.3: -10 °C
8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 20 °C
9.1: ethanol; tetrahydrofuran / 36 h / 50 °C
With
1H-imidazole; n-butyllithium; tetrabutyl ammonium fluoride; water; potassium hexamethylsilazane; phenyllithium; sodium hydroxide; trichlorophosphate;
In
tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dibutyl ether; N,N-dimethyl-formamide;