5-[2-[2-benzyloxy-4-[butyl(4-hydroxybutyl)amino]phenyl]vinyl]thiophene-2-carboaldehyde

Base Information

Chemical Name:5-[2-[2-benzyloxy-4-[butyl(4-hydroxybutyl)amino]phenyl]vinyl]thiophene-2-carboaldehyde
CAS No.:1267606-12-1
Molecular Formula:C₂₈H₃₃NO₃S
Molecular Weight:463.641
Hs Code.:

Synonyms:5-[2-[2-benzyloxy-4-[butyl(4-hydroxybutyl)amino]phenyl]vinyl]thiophene-2-carboaldehyde

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Chemical Property of 5-[2-[2-benzyloxy-4-[butyl(4-hydroxybutyl)amino]phenyl]vinyl]thiophene-2-carboaldehyde

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Technology Process of 5-[2-[2-benzyloxy-4-[butyl(4-hydroxybutyl)amino]phenyl]vinyl]thiophene-2-carboaldehyde

There total 8 articles about 5-[2-[2-benzyloxy-4-[butyl(4-hydroxybutyl)amino]phenyl]vinyl]thiophene-2-carboaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1267606-06-3
2-benzyloxy-4-[butyl(4-hydroxybutyl)amino]benzaldehyde

: 1267606-12-1
5-[2-[2-benzyloxy-4-[butyl(4-hydroxybutyl)amino]phenyl]vinyl]thiophene-2-carboaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: phenyllithium / dibutyl ether; tetrahydrofuran / 0.25 h / Cooling with ice; Inert atmosphere

2.2: 2.13 h / Cooling with ice; Inert atmosphere

3.1: n-butyllithium / hexane; tetrahydrofuran / 0.58 h / -72 - -66 °C / Inert atmosphere

3.2: 1.5 h / -72 - -10 °C / Inert atmosphere

3.3: -10 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 20 °C

With 1H-imidazole; n-butyllithium; tetrabutyl ammonium fluoride; phenyllithium; In tetrahydrofuran; hexane; dibutyl ether; N,N-dimethyl-formamide;

Reference yield:

: 1267606-07-4
2-benzyloxy-4-[butyl[4-(tert-butyldiphenylsiloxy) butyl]amino]benzaldehyde

: 1267606-12-1
5-[2-[2-benzyloxy-4-[butyl(4-hydroxybutyl)amino]phenyl]vinyl]thiophene-2-carboaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: phenyllithium / dibutyl ether; tetrahydrofuran / 0.25 h / Cooling with ice; Inert atmosphere

1.2: 2.13 h / Cooling with ice; Inert atmosphere

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.58 h / -72 - -66 °C / Inert atmosphere

2.2: 1.5 h / -72 - -10 °C / Inert atmosphere

2.3: -10 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 20 °C

With n-butyllithium; tetrabutyl ammonium fluoride; phenyllithium; In tetrahydrofuran; hexane; dibutyl ether;

Reference yield:

: 1267606-10-9
[3-benzyloxy-4-(2-thiophene-2-ylvinyl)phenyl]butyl[4-(tert-butyldiphenylsiloxy) butyl]amine

: 1267606-12-1
5-[2-[2-benzyloxy-4-[butyl(4-hydroxybutyl)amino]phenyl]vinyl]thiophene-2-carboaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.58 h / -72 - -66 °C / Inert atmosphere

1.2: 1.5 h / -72 - -10 °C / Inert atmosphere

1.3: -10 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 20 °C

With n-butyllithium; tetrabutyl ammonium fluoride; In tetrahydrofuran; hexane;