N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-2-phenylacrylamide

Base Information

Chemical Name:N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-2-phenylacrylamide
CAS No.:1068602-48-1
Molecular Formula:C₁₉H₂₁NO₂
Molecular Weight:295.381
Hs Code.:

Synonyms:N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-2-phenylacrylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-2-phenylacrylamide

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Technology Process of N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-2-phenylacrylamide

There total 1 articles about N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-2-phenylacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 159213-05-5
pseudoephedrine benzeneacetamide

: 1068602-48-1
N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-2-phenylacrylamide

Guidance literature:: With tetrabutylammomium bromide; caesium carbonate; In N,N-dimethyl-formamide; at 23 - 80 ℃; Inert atmosphere;
DOI:10.1021/ja806021y

Reference yield: 82.0%

: 7751-38-4
Diisopropylsilyl dichloride

: 1068602-48-1
N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-2-phenylacrylamide

: 917-54-4
methyllithium

: 1068601-55-7
C₂₆H₃₇NO₂Si

Guidance literature:: N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-2-phenylacrylamide; methyllithium; With lithium chloride; In tetrahydrofuran; formaldehyde diethyl acetal; at -78 ℃; Inert atmosphere;

Diisopropylsilyl dichloride; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; In tetrahydrofuran; formaldehyde diethyl acetal; at -78 ℃; for 1h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ja806021y

Reference yield:

: 7751-38-4
Diisopropylsilyl dichloride

: 1068602-48-1
N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-2-phenylacrylamide

: 917-54-4
methyllithium

: C₂₆H₃₇NO₂Si

: 1068601-55-7
C₂₆H₃₇NO₂Si

Guidance literature:: N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-2-phenylacrylamide; methyllithium; With lithium chloride; In tetrahydrofuran; formaldehyde diethyl acetal; at -78 - -40 ℃; Inert atmosphere;

Diisopropylsilyl dichloride; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; In tetrahydrofuran; formaldehyde diethyl acetal; at -78 ℃; for 1h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ja806021y