4-(3-chloro-4-methoxy-benzylamino)-6-amino-7-methoxy-8-propyl-quinazoline

Base Information

Chemical Name:4-(3-chloro-4-methoxy-benzylamino)-6-amino-7-methoxy-8-propyl-quinazoline
CAS No.:1007308-63-5
Molecular Formula:C₂₀H₂₃ClN₄O₂
Molecular Weight:386.881
Hs Code.:

Synonyms:4-(3-chloro-4-methoxy-benzylamino)-6-amino-7-methoxy-8-propyl-quinazoline

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Chemical Property of 4-(3-chloro-4-methoxy-benzylamino)-6-amino-7-methoxy-8-propyl-quinazoline

Chemical Property:

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Technology Process of 4-(3-chloro-4-methoxy-benzylamino)-6-amino-7-methoxy-8-propyl-quinazoline

There total 8 articles about 4-(3-chloro-4-methoxy-benzylamino)-6-amino-7-methoxy-8-propyl-quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53449-14-2
7-chloro-6-nitro-4(3H)-quinazolinone

: 1007308-63-5
4-(3-chloro-4-methoxy-benzylamino)-6-amino-7-methoxy-8-propyl-quinazoline

Guidance literature:: Multi-step reaction with 8 steps

1: thionyl chloride / N,N-dimethyl-formamide / 17 h / 20 °C / Heating / reflux

2: triethylamine / N,N-dimethyl-formamide / isopropyl alcohol / 17 h / 20 °C

3: methanol / 16 h / Heating / reflux

4: lithium chloride / N,N-dimethyl-formamide / 5 h / 150 °C

5: potassium carbonate / acetone / 6 h / 80 °C

6: xylene / 2 h / 150 °C

7: potassium carbonate / acetone / 5 h / 20 °C / Heating / reflux

8: hydrogen; potassium carbonate / platinum(IV) oxide / methanol / 2 h / 20 °C

With thionyl chloride; hydrogen; potassium carbonate; triethylamine; lithium chloride; platinum(IV) oxide; N,N-dimethyl-formamide; In methanol; N,N-dimethyl-formamide; isopropyl alcohol; acetone; xylene;

Reference yield:

: 1007307-68-7
(8-allyl-7-methoxy-6-nitro-quinazolin-4-yl)-(3-chloro-4-methoxy-benzyl)-amine

: 1007308-63-5
4-(3-chloro-4-methoxy-benzylamino)-6-amino-7-methoxy-8-propyl-quinazoline

Guidance literature:: With platinum(IV) oxide; hydrogen; In methanol;
DOI:10.1016/j.bmcl.2008.09.108

Reference yield:

: 1007308-62-4
C₁₉H₁₇ClN₄O₄

: 1007308-63-5
4-(3-chloro-4-methoxy-benzylamino)-6-amino-7-methoxy-8-propyl-quinazoline

Guidance literature:: Multi-step reaction with 3 steps

1: xylene / 2 h / 150 °C

2: potassium carbonate / acetone / 5 h / 20 °C / Heating / reflux

3: hydrogen; potassium carbonate / platinum(IV) oxide / methanol / 2 h / 20 °C

With hydrogen; potassium carbonate; platinum(IV) oxide; In methanol; acetone; xylene;