2-chloro-N-[4-(3-chloro-4-methoxy-benzylamino)-7-methoxy-8-propyl-quinazolin-6-yl]-acetamide

Base Information

Chemical Name:2-chloro-N-[4-(3-chloro-4-methoxy-benzylamino)-7-methoxy-8-propyl-quinazolin-6-yl]-acetamide
CAS No.:1007307-94-9
Molecular Formula:C₂₂H₂₄Cl₂N₄O₃
Molecular Weight:463.364
Hs Code.:

Synonyms:2-chloro-N-[4-(3-chloro-4-methoxy-benzylamino)-7-methoxy-8-propyl-quinazolin-6-yl]-acetamide

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Chemical Property of 2-chloro-N-[4-(3-chloro-4-methoxy-benzylamino)-7-methoxy-8-propyl-quinazolin-6-yl]-acetamide

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Technology Process of 2-chloro-N-[4-(3-chloro-4-methoxy-benzylamino)-7-methoxy-8-propyl-quinazolin-6-yl]-acetamide

There total 10 articles about 2-chloro-N-[4-(3-chloro-4-methoxy-benzylamino)-7-methoxy-8-propyl-quinazolin-6-yl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1007308-63-5
4-(3-chloro-4-methoxy-benzylamino)-6-amino-7-methoxy-8-propyl-quinazoline

: 79-04-9
chloroacetyl chloride

: 1007307-94-9
2-chloro-N-[4-(3-chloro-4-methoxy-benzylamino)-7-methoxy-8-propyl-quinazolin-6-yl]-acetamide

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

: 53449-14-2
7-chloro-6-nitro-4(3H)-quinazolinone

: 1007307-94-9
2-chloro-N-[4-(3-chloro-4-methoxy-benzylamino)-7-methoxy-8-propyl-quinazolin-6-yl]-acetamide

Guidance literature:: Multi-step reaction with 9 steps

1: thionyl chloride / N,N-dimethyl-formamide / 17 h / 20 °C / Heating / reflux

2: triethylamine / N,N-dimethyl-formamide / isopropyl alcohol / 17 h / 20 °C

3: methanol / 16 h / Heating / reflux

4: lithium chloride / N,N-dimethyl-formamide / 5 h / 150 °C

5: potassium carbonate / acetone / 6 h / 80 °C

6: xylene / 2 h / 150 °C

7: potassium carbonate / acetone / 5 h / 20 °C / Heating / reflux

8: hydrogen; potassium carbonate / platinum(IV) oxide / methanol / 2 h / 20 °C

9: pyridine / dichloromethane / 1 h / 0 - 20 °C

With pyridine; thionyl chloride; hydrogen; potassium carbonate; triethylamine; lithium chloride; platinum(IV) oxide; N,N-dimethyl-formamide; In methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetone; xylene;

Reference yield:

: 1007308-62-4
C₁₉H₁₇ClN₄O₄

: 1007307-94-9
2-chloro-N-[4-(3-chloro-4-methoxy-benzylamino)-7-methoxy-8-propyl-quinazolin-6-yl]-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: xylene / 2 h / 150 °C

2: potassium carbonate / acetone / 5 h / 20 °C / Heating / reflux

3: hydrogen; potassium carbonate / platinum(IV) oxide / methanol / 2 h / 20 °C

4: pyridine / dichloromethane / 1 h / 0 - 20 °C

With pyridine; hydrogen; potassium carbonate; platinum(IV) oxide; In methanol; dichloromethane; acetone; xylene;