4-[hydroxy-(4-methoxyphenyl)]methyl-5-(4-methoxy-benzyl)-1-methyl-1H-imidazole

Base Information

Chemical Name:4-[hydroxy-(4-methoxyphenyl)]methyl-5-(4-methoxy-benzyl)-1-methyl-1H-imidazole
CAS No.:1206617-48-2
Molecular Formula:C₂₀H₂₂N₂O₃
Molecular Weight:338.406
Hs Code.:

Synonyms:4-[hydroxy-(4-methoxyphenyl)]methyl-5-(4-methoxy-benzyl)-1-methyl-1H-imidazole

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Chemical Property of 4-[hydroxy-(4-methoxyphenyl)]methyl-5-(4-methoxy-benzyl)-1-methyl-1H-imidazole

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Technology Process of 4-[hydroxy-(4-methoxyphenyl)]methyl-5-(4-methoxy-benzyl)-1-methyl-1H-imidazole

There total 5 articles about 4-[hydroxy-(4-methoxyphenyl)]methyl-5-(4-methoxy-benzyl)-1-methyl-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 104-92-7
1-bromo-4-methoxy-benzene

: 1206617-47-1
5-4-methoxybenzyl-1-methyl-1H-imidazole-4-carbaldehyde

: 1206617-48-2
4-[hydroxy-(4-methoxyphenyl)]methyl-5-(4-methoxy-benzyl)-1-methyl-1H-imidazole

Guidance literature:: 1-bromo-4-methoxy-benzene; With magnesium; In tetrahydrofuran;

5-4-methoxybenzyl-1-methyl-1H-imidazole-4-carbaldehyde; In tetrahydrofuran; Reflux;
DOI:10.1016/j.bmc.2017.01.024

Reference yield: 98.0%

: 1206617-47-1
5-4-methoxybenzyl-1-methyl-1H-imidazole-4-carbaldehyde

: 13139-86-1
4-methoxyphenyl magnesium bromide

: 1206617-48-2
4-[hydroxy-(4-methoxyphenyl)]methyl-5-(4-methoxy-benzyl)-1-methyl-1H-imidazole

Guidance literature:: In tetrahydrofuran; Reflux;
DOI:10.1016/j.tetlet.2009.10.117

Reference yield:

: 1197054-82-2
(4-iodo-1-methyl-1H-imidazol-5-yl)(4-methoxyphenyl)methanol

: 1206617-48-2
4-[hydroxy-(4-methoxyphenyl)]methyl-5-(4-methoxy-benzyl)-1-methyl-1H-imidazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylsilane; boron trifluoride diethyl etherate / tetrahydrofuran / 24 h / 0 - 60 °C / Inert atmosphere

2.1: ethylmagnesium bromide / tetrahydrofuran / 0.5 h / 25 °C / Inert atmosphere

2.2: 12 h / 25 °C / Inert atmosphere

3.1: tetrahydrofuran / 12 h / 25 °C / Inert atmosphere

With triethylsilane; boron trifluoride diethyl etherate; ethylmagnesium bromide; In tetrahydrofuran;
DOI:10.1016/j.ejmech.2014.06.016