N-2-propynyl-N'-2-(4,4’-dimethoxytrityloxy)ethyl-N'-2-(2-cyanoethoxy-N,N-diisopropylaminophosphinyloxy)ethyloxalamide

Base Information

Chemical Name:N-2-propynyl-N'-2-(4,4’-dimethoxytrityloxy)ethyl-N'-2-(2-cyanoethoxy-N,N-diisopropylaminophosphinyloxy)ethyloxalamide
CAS No.:1609931-51-2
Molecular Formula:C₃₉H₄₉N₄O₇P
Molecular Weight:716.814
Hs Code.:

Synonyms:N-2-propynyl-N'-2-(4,4’-dimethoxytrityloxy)ethyl-N'-2-(2-cyanoethoxy-N,N-diisopropylaminophosphinyloxy)ethyloxalamide

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Chemical Property of N-2-propynyl-N'-2-(4,4’-dimethoxytrityloxy)ethyl-N'-2-(2-cyanoethoxy-N,N-diisopropylaminophosphinyloxy)ethyloxalamide

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Technology Process of N-2-propynyl-N'-2-(4,4’-dimethoxytrityloxy)ethyl-N'-2-(2-cyanoethoxy-N,N-diisopropylaminophosphinyloxy)ethyloxalamide

There total 3 articles about N-2-propynyl-N'-2-(4,4’-dimethoxytrityloxy)ethyl-N'-2-(2-cyanoethoxy-N,N-diisopropylaminophosphinyloxy)ethyloxalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1609931-50-1
N-2-propynyl-N'-2-(4,4'-dimethoxytrityloxy)ethyl-N'-2-hydroxyethyloxalamide

: 102691-36-1
N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

: 1609931-51-2
N-2-propynyl-N'-2-(4,4’-dimethoxytrityloxy)ethyl-N'-2-(2-cyanoethoxy-N,N-diisopropylaminophosphinyloxy)ethyloxalamide

Guidance literature:: N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite; With 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 0.5h;

N-2-propynyl-N'-2-(4,4'-dimethoxytrityloxy)ethyl-N'-2-hydroxyethyloxalamide; In acetonitrile; at 20 ℃; for 2.53333h;
DOI:10.1021/ol500668n

Reference yield:

: 1397704-93-6
4-(2-(4,4' dimethoxytrityloxy)ethyl)morpholine 2,3 dione

: 1609931-51-2
N-2-propynyl-N'-2-(4,4’-dimethoxytrityloxy)ethyl-N'-2-(2-cyanoethoxy-N,N-diisopropylaminophosphinyloxy)ethyloxalamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / 16 h / 65 °C

2.1: 1H-tetrazole; N-ethyl-N,N-diisopropylamine / acetonitrile / 0.5 h / 20 °C

2.2: 2.53 h / 20 °C

With pyridine; 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In acetonitrile;
DOI:10.1021/ol500668n

Reference yield:

: 68898-62-4
N-(2-hydroxyethyl)morpholine-2,3-dione

: 1609931-51-2
N-2-propynyl-N'-2-(4,4’-dimethoxytrityloxy)ethyl-N'-2-(2-cyanoethoxy-N,N-diisopropylaminophosphinyloxy)ethyloxalamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 3 h / 20 °C

2.1: pyridine / 16 h / 65 °C

3.1: 1H-tetrazole; N-ethyl-N,N-diisopropylamine / acetonitrile / 0.5 h / 20 °C

3.2: 2.53 h / 20 °C

With pyridine; 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In acetonitrile;
DOI:10.1021/ol500668n