N-2-propynyl-N'-2-(4,4'-dimethoxytrityloxy)ethyl-N'-2-hydroxyethyloxalamide

Base Information

Chemical Name:N-2-propynyl-N'-2-(4,4'-dimethoxytrityloxy)ethyl-N'-2-hydroxyethyloxalamide
CAS No.:1609931-50-1
Molecular Formula:C₃₀H₃₂N₂O₆
Molecular Weight:516.594
Hs Code.:

Synonyms:N-2-propynyl-N'-2-(4,4'-dimethoxytrityloxy)ethyl-N'-2-hydroxyethyloxalamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-2-propynyl-N'-2-(4,4'-dimethoxytrityloxy)ethyl-N'-2-hydroxyethyloxalamide

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Technology Process of N-2-propynyl-N'-2-(4,4'-dimethoxytrityloxy)ethyl-N'-2-hydroxyethyloxalamide

There total 2 articles about N-2-propynyl-N'-2-(4,4'-dimethoxytrityloxy)ethyl-N'-2-hydroxyethyloxalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1397704-93-6
4-(2-(4,4' dimethoxytrityloxy)ethyl)morpholine 2,3 dione

: 2450-71-7
Propargylamine

: 1609931-50-1
N-2-propynyl-N'-2-(4,4'-dimethoxytrityloxy)ethyl-N'-2-hydroxyethyloxalamide

Guidance literature:: With pyridine; at 65 ℃; for 16h;
DOI:10.1021/ol500668n

Reference yield:

: 68898-62-4
N-(2-hydroxyethyl)morpholine-2,3-dione

: 1609931-50-1
N-2-propynyl-N'-2-(4,4'-dimethoxytrityloxy)ethyl-N'-2-hydroxyethyloxalamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 3 h / 20 °C

2: pyridine / 16 h / 65 °C

With pyridine;
DOI:10.1021/ol500668n

Reference yield: 39.0%

: 1609931-50-1
N-2-propynyl-N'-2-(4,4'-dimethoxytrityloxy)ethyl-N'-2-hydroxyethyloxalamide

: 102691-36-1
N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

: 1609931-51-2
N-2-propynyl-N'-2-(4,4’-dimethoxytrityloxy)ethyl-N'-2-(2-cyanoethoxy-N,N-diisopropylaminophosphinyloxy)ethyloxalamide

Guidance literature:: N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite; With 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 0.5h;

N-2-propynyl-N'-2-(4,4'-dimethoxytrityloxy)ethyl-N'-2-hydroxyethyloxalamide; In acetonitrile; at 20 ℃; for 2.53333h;
DOI:10.1021/ol500668n