(R)-methyl 5-(4-(4,5-dimethyl-6-(phenylamino)pyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazine-2-carboxylate

Base Information

Chemical Name:(R)-methyl 5-(4-(4,5-dimethyl-6-(phenylamino)pyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazine-2-carboxylate
CAS No.:1204973-76-1
Molecular Formula:C₂₃H₂₇N₇O₂
Molecular Weight:433.513
Hs Code.:

Synonyms:(R)-methyl 5-(4-(4,5-dimethyl-6-(phenylamino)pyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazine-2-carboxylate

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Chemical Property of (R)-methyl 5-(4-(4,5-dimethyl-6-(phenylamino)pyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazine-2-carboxylate

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Technology Process of (R)-methyl 5-(4-(4,5-dimethyl-6-(phenylamino)pyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazine-2-carboxylate

There total 4 articles about (R)-methyl 5-(4-(4,5-dimethyl-6-(phenylamino)pyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1204978-36-8
(R)-4-(6-chloro-4,5-dimethyl-pyridazin-3-yl)-2-methyl-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl-5'-carboxylic acid methyl ester

: 62-53-3
aniline

: 1204973-76-1
(R)-methyl 5-(4-(4,5-dimethyl-6-(phenylamino)pyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazine-2-carboxylate

: 1204973-77-2
(R)-4-(4,5-dimethyl-6-phenylaminopyridazin-3-yl)-2-methyl-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl-5'-carboxylic acid phenylamide

Guidance literature:: at 190 ℃; for 0.5h; microwave irradiation;

Reference yield:

: 75336-86-6
(2R)-methylpiperazine

: 1204973-76-1
(R)-methyl 5-(4-(4,5-dimethyl-6-(phenylamino)pyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazine-2-carboxylate

: 1204973-77-2
(R)-4-(4,5-dimethyl-6-phenylaminopyridazin-3-yl)-2-methyl-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl-5'-carboxylic acid phenylamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 60 °C

2: triethylamine / 1,4-dioxane / 24 h / 80 °C

3: 0.5 h / 190 °C / Microwave irradiation

With potassium carbonate; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201300217

Reference yield:

: 1204978-32-4
3-chloro-4,5-dimethyl-6-((R)-3-methyl-piperazin-1-yl)-pyridazine

: 1204973-76-1
(R)-methyl 5-(4-(4,5-dimethyl-6-(phenylamino)pyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazine-2-carboxylate

: 1204973-77-2
(R)-4-(4,5-dimethyl-6-phenylaminopyridazin-3-yl)-2-methyl-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl-5'-carboxylic acid phenylamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / 1,4-dioxane / 24 h / 80 °C

2: 0.5 h / 190 °C / Microwave irradiation

With triethylamine; In 1,4-dioxane;
DOI:10.1002/cmdc.201300217