(R)-2-(5-(4-(4,5-dimethyl-6-(phenylamino)pyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazin-2-yl)propan-2-ol

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Chemical Name:(R)-2-(5-(4-(4,5-dimethyl-6-(phenylamino)pyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazin-2-yl)propan-2-ol
CAS No.:1204973-80-7
Molecular Formula:C₂₄H₃₁N₇O
Molecular Weight:433.556
Hs Code.:

Synonyms:(R)-2-(5-(4-(4,5-dimethyl-6-(phenylamino)pyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazin-2-yl)propan-2-ol

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Chemical Property of (R)-2-(5-(4-(4,5-dimethyl-6-(phenylamino)pyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazin-2-yl)propan-2-ol

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Technology Process of (R)-2-(5-(4-(4,5-dimethyl-6-(phenylamino)pyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazin-2-yl)propan-2-ol

There total 5 articles about (R)-2-(5-(4-(4,5-dimethyl-6-(phenylamino)pyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazin-2-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1204973-76-1
(R)-methyl 5-(4-(4,5-dimethyl-6-(phenylamino)pyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazine-2-carboxylate

: 75-16-1
methylmagnesium bromide

: 1204973-80-7
(R)-2-(5-(4-(4,5-dimethyl-6-(phenylamino)pyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazin-2-yl)propan-2-ol

Guidance literature:: (R)-methyl 5-(4-(4,5-dimethyl-6-(phenylamino)pyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazine-2-carboxylate; methylmagnesium bromide; In tetrahydrofuran; at -78 - 0 ℃; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; at -78 ℃;

Reference yield:

: 75336-86-6
(2R)-methylpiperazine

: 1204973-80-7
(R)-2-(5-(4-(4,5-dimethyl-6-(phenylamino)pyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazin-2-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 60 °C

2: triethylamine / 1,4-dioxane / 24 h / 80 °C

3: 0.5 h / 190 °C / Microwave irradiation

4: tetrahydrofuran; diethyl ether / 3.5 h / -78 - 0 °C / Inert atmosphere

With potassium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201300217

Reference yield:

: 34584-69-5
3,6-dichloro-4,5-dimethylpyridazine

: 1204973-80-7
(R)-2-(5-(4-(4,5-dimethyl-6-(phenylamino)pyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazin-2-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 60 °C

2: triethylamine / 1,4-dioxane / 24 h / 80 °C

3: 0.5 h / 190 °C / Microwave irradiation

4: tetrahydrofuran; diethyl ether / 3.5 h / -78 - 0 °C / Inert atmosphere

With potassium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201300217