2-(trifluoromethyl)-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]-thiadiazole-5-carbaldehyde

Base Information

• Chemical Name: 2-(trifluoromethyl)-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]-thiadiazole-5-carbaldehyde
• CAS No.: 1070653-35-8
• Molecular Formula: C₁₂H₅F₄N₃OS
• Molecular Weight: 315.251

Synonyms:2-(trifluoromethyl)-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]-thiadiazole-5-carbaldehyde

Chemical Property of 2-(trifluoromethyl)-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]-thiadiazole-5-carbaldehyde

Chemical Property:

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Technology Process of 2-(trifluoromethyl)-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]-thiadiazole-5-carbaldehyde

There total 1 articles about 2-(trifluoromethyl)-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]-thiadiazole-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 2-(trifluoromethyl)-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]-thiadiazole (368841-71-8) → 2-(trifluoromethyl)-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]-thiadiazole-5-carbaldehyde (1070653-35-8)

Guidance literature:

With trichlorophosphate; at 0 - 60 ℃; for 4.5h;

DOI:10.1016/j.bmcl.2012.01.052

Reference yield: 76.0%

rhodanine 3-acetic acid (5718-83-2) + 2-(trifluoromethyl)-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]-thiadiazole-5-carbaldehyde (1070653-35-8) → 2-((5Z)-5-((2-(trifluoromethyl)-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]-thiadiazol-5-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid (1365994-61-1)

Guidance literature:

With piperidinyl acetate; Neat (no solvent); Microwave irradiation;

DOI:10.1016/j.bmcl.2012.01.052

Reference yield: 72.0%

2-thioxo-4-thiazolidinone (141-84-4) + 2-(trifluoromethyl)-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]-thiadiazole-5-carbaldehyde (1070653-35-8) → 5-((2-(trifluoromethyl)-6-(4-fluorophenyl)-imidazo[2,1-b][1,3,4]-thiadiazol-5-yl)methylene)-2-thioxothiazolidin-4-one (1365994-54-2)

Guidance literature:

With piperidinyl acetate; Neat (no solvent); Microwave irradiation;

DOI:10.1016/j.bmcl.2012.01.052

upstream raw materials:

N,N-dimethyl-formamide

2-(trifluoromethyl)-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]-thiadiazole

Downstream raw materials:

5-((2-(trifluoromethyl)-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]-thiadiazol-5-yl)methylene)thiazolidine-2,4-dione

5-((2-(trifluoromethyl)-6-(4-fluorophenyl)-imidazo[2,1-b][1,3,4]-thiadiazol-5-yl)methylene)-2-thioxothiazolidin-4-one

2-((5Z)-5-((2-(trifluoromethyl)-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]-thiadiazol-5-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid

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