methyl 2-acetamido-4-(2-acetamido-4-amino-5-methoxybenzamido)-5-methoxybenzoate

Base Information

Chemical Name:methyl 2-acetamido-4-(2-acetamido-4-amino-5-methoxybenzamido)-5-methoxybenzoate
CAS No.:1378949-48-4
Molecular Formula:C₂₁H₂₄N₄O₇
Molecular Weight:444.444
Hs Code.:

Synonyms:methyl 2-acetamido-4-(2-acetamido-4-amino-5-methoxybenzamido)-5-methoxybenzoate

Suppliers and Price of methyl 2-acetamido-4-(2-acetamido-4-amino-5-methoxybenzamido)-5-methoxybenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of methyl 2-acetamido-4-(2-acetamido-4-amino-5-methoxybenzamido)-5-methoxybenzoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of methyl 2-acetamido-4-(2-acetamido-4-amino-5-methoxybenzamido)-5-methoxybenzoate

There total 5 articles about methyl 2-acetamido-4-(2-acetamido-4-amino-5-methoxybenzamido)-5-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1378949-43-9
methyl 2-acetamido-4-(2-acetamido-5-methoxy-4-nitrobenzamido)-5-methoxybenzoate

: 1378949-48-4
methyl 2-acetamido-4-(2-acetamido-4-amino-5-methoxybenzamido)-5-methoxybenzoate

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; In methanol; dichloromethane; for 20h;
DOI:10.1016/j.tet.2011.11.010

Reference yield:

: 196194-97-5
N-(4-methoxy-2-methyl-5-nitrophenyl)acetamide

: 1378949-48-4
methyl 2-acetamido-4-(2-acetamido-4-amino-5-methoxybenzamido)-5-methoxybenzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium permanganate; magnesium sulfate / water / 1.5 h / 80 °C / Inert atmosphere

2.1: hydrogenchloride / water / 5 h / Reflux; Inert atmosphere

3.1: thionyl chloride / 1 h / Inert atmosphere; Reflux

3.2: 18 h / Inert atmosphere; Reflux

4.1: dmap / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

5.1: 5%-palladium/activated carbon; hydrogen / methanol; dichloromethane / 20 h

With hydrogenchloride; dmap; potassium permanganate; thionyl chloride; 5%-palladium/activated carbon; hydrogen; magnesium sulfate; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2011.11.010

Reference yield:

: 102-50-1
2-methyl-4-methoxyaniline

: 1378949-48-4
methyl 2-acetamido-4-(2-acetamido-4-amino-5-methoxybenzamido)-5-methoxybenzoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine / 0 - 20 °C / Inert atmosphere

2.1: trifluoroacetic acid; sodium nitrite / 0 - 20 °C / Inert atmosphere

3.1: potassium permanganate; magnesium sulfate / water / 1.5 h / 80 °C / Inert atmosphere

4.1: hydrogenchloride / water / 5 h / Reflux; Inert atmosphere

5.1: thionyl chloride / 1 h / Inert atmosphere; Reflux

5.2: 18 h / Inert atmosphere; Reflux

6.1: dmap / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

7.1: 5%-palladium/activated carbon; hydrogen / methanol; dichloromethane / 20 h

With pyridine; hydrogenchloride; dmap; potassium permanganate; thionyl chloride; 5%-palladium/activated carbon; hydrogen; magnesium sulfate; trifluoroacetic acid; sodium nitrite; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2011.11.010