methyl 2-acetamido-4-(2-acetamido-4-(2-acetamido-5-methoxy-4-nitrobenzamido)-5-methoxybenzamido)-5-methoxybenzoate

Base Information

Chemical Name:methyl 2-acetamido-4-(2-acetamido-4-(2-acetamido-5-methoxy-4-nitrobenzamido)-5-methoxybenzamido)-5-methoxybenzoate
CAS No.:1378949-53-1
Molecular Formula:C₃₁H₃₂N₆O₁₂
Molecular Weight:680.628
Hs Code.:

Synonyms:methyl 2-acetamido-4-(2-acetamido-4-(2-acetamido-5-methoxy-4-nitrobenzamido)-5-methoxybenzamido)-5-methoxybenzoate

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Chemical Property of methyl 2-acetamido-4-(2-acetamido-4-(2-acetamido-5-methoxy-4-nitrobenzamido)-5-methoxybenzamido)-5-methoxybenzoate

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Technology Process of methyl 2-acetamido-4-(2-acetamido-4-(2-acetamido-5-methoxy-4-nitrobenzamido)-5-methoxybenzamido)-5-methoxybenzoate

There total 9 articles about methyl 2-acetamido-4-(2-acetamido-4-(2-acetamido-5-methoxy-4-nitrobenzamido)-5-methoxybenzamido)-5-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1378949-50-8
methyl 2-acetamido-4-(2-acetamido-4-(2-amino-5-methoxy-4-nitrobenzamido)-5-methoxybenzamido)-5-methoxybenzoate hydrochloride

: 75-36-5
acetyl chloride

: 1378949-53-1
methyl 2-acetamido-4-(2-acetamido-4-(2-acetamido-5-methoxy-4-nitrobenzamido)-5-methoxybenzamido)-5-methoxybenzoate

Guidance literature:: With dmap; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2011.11.010

Reference yield:

: 102-50-1
2-methyl-4-methoxyaniline

: 1378949-53-1
methyl 2-acetamido-4-(2-acetamido-4-(2-acetamido-5-methoxy-4-nitrobenzamido)-5-methoxybenzamido)-5-methoxybenzoate

Guidance literature:: Multi-step reaction with 10 steps

1.1: pyridine / 0 - 20 °C / Inert atmosphere

2.1: trifluoroacetic acid; sodium nitrite / 0 - 20 °C / Inert atmosphere

3.1: potassium permanganate; magnesium sulfate / water / 1.5 h / 80 °C / Inert atmosphere

4.1: potassium carbonate / N,N-dimethyl-formamide / 70 °C / Inert atmosphere

5.1: 5%-palladium/activated carbon; hydrogen / methanol; dichloromethane / 20 h

6.1: thionyl chloride / 1 h / Inert atmosphere; Reflux

6.2: 18 h / Inert atmosphere; Reflux

7.1: dmap / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

8.1: 5%-palladium/activated carbon; hydrogen / methanol; dichloromethane / 20 h

9.1: thionyl chloride / 1 h / Inert atmosphere; Reflux

9.2: 18 h / Inert atmosphere; Reflux

10.1: dmap / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With pyridine; dmap; potassium permanganate; thionyl chloride; 5%-palladium/activated carbon; hydrogen; magnesium sulfate; potassium carbonate; trifluoroacetic acid; sodium nitrite; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2011.11.010

Reference yield:

: 31601-41-9
N-(4-methoxy-2-methylphenyl)acetamide

: 1378949-53-1
methyl 2-acetamido-4-(2-acetamido-4-(2-acetamido-5-methoxy-4-nitrobenzamido)-5-methoxybenzamido)-5-methoxybenzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid; sodium nitrite / 0 - 20 °C / Inert atmosphere

2.1: potassium permanganate; magnesium sulfate / water / 1.5 h / 80 °C / Inert atmosphere

3.1: hydrogenchloride / water / 5 h / Reflux; Inert atmosphere

4.1: thionyl chloride / 1 h / Inert atmosphere; Reflux

4.2: 18 h / Inert atmosphere; Reflux

5.1: dmap / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; dmap; potassium permanganate; thionyl chloride; magnesium sulfate; trifluoroacetic acid; sodium nitrite; In water; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2011.11.010