5'-O-DMT thymidylyl (3',5')-3'-O-acetylthymidine 5'-methanephosphonate

Base Information

Chemical Name:5'-O-DMT thymidylyl (3',5')-3'-O-acetylthymidine 5'-methanephosphonate
CAS No.:90814-42-9
Molecular Formula:C₄₄H₄₉N₄O₁₄P
Molecular Weight:888.865
Hs Code.:

Synonyms:5'-O-DMT thymidylyl (3',5')-3'-O-acetylthymidine 5'-methanephosphonate

Suppliers and Price of 5'-O-DMT thymidylyl (3',5')-3'-O-acetylthymidine 5'-methanephosphonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 5'-O-DMT thymidylyl (3',5')-3'-O-acetylthymidine 5'-methanephosphonate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of 5'-O-DMT thymidylyl (3',5')-3'-O-acetylthymidine 5'-methanephosphonate

There total 11 articles about 5'-O-DMT thymidylyl (3',5')-3'-O-acetylthymidine 5'-methanephosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 21090-30-2
3'-O-acetylthymidine

: 160971-73-3
(Rp)-5'-O-DMT-thymidine-3'-O-(Se-methyl methanephosphonoselenolate)

: 90814-42-9
5'-O-DMT thymidylyl (3',5')-3'-O-acetylthymidine 5'-methanephosphonate

Guidance literature:: With triethylamine trihydrofluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane; acetonitrile; for 0.166667h;
DOI:10.1021/jo951333v

Reference yield:

: 160971-73-3
(Rp)-5'-O-DMT-thymidine-3'-O-(Se-methyl methanephosphonoselenolate)

: 90814-42-9
5'-O-DMT thymidylyl (3',5')-3'-O-acetylthymidine 5'-methanephosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / AgF / acetonitrile; H₂O / 0.08 h / Ambient temperature

2: DBU / acetonitrile / 0.33 h / Ambient temperature

With silver fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In water; acetonitrile;
DOI:10.1021/jo951333v

Reference yield:

: 21090-30-2
3'-O-acetylthymidine

: 174955-63-6
5'-O-(dimethoxytrityl)thymidine 3'-O-methylphosphonofluoridate

: 90814-42-9
5'-O-DMT thymidylyl (3',5')-3'-O-acetylthymidine 5'-methanephosphonate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; for 0.333333h; Yield given; Ambient temperature;
DOI:10.1021/jo951333v