(2R,3R,5R)-5-Butyl-3-diphenylphosphinoyl-2-phenyl-2-trimethylsilyloxytetrahydrofuran

Base Information

Chemical Name:(2R,3R,5R)-5-Butyl-3-diphenylphosphinoyl-2-phenyl-2-trimethylsilyloxytetrahydrofuran
CAS No.:176242-53-8
Molecular Formula:C₂₉H₃₇O₃PSi
Molecular Weight:492.67
Hs Code.:

Synonyms:(2R,3R,5R)-5-Butyl-3-diphenylphosphinoyl-2-phenyl-2-trimethylsilyloxytetrahydrofuran

Suppliers and Price of (2R,3R,5R)-5-Butyl-3-diphenylphosphinoyl-2-phenyl-2-trimethylsilyloxytetrahydrofuran

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R,5R)-5-Butyl-3-diphenylphosphinoyl-2-phenyl-2-trimethylsilyloxytetrahydrofuran

Chemical Property:

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Technology Process of (2R,3R,5R)-5-Butyl-3-diphenylphosphinoyl-2-phenyl-2-trimethylsilyloxytetrahydrofuran

There total 6 articles about (2R,3R,5R)-5-Butyl-3-diphenylphosphinoyl-2-phenyl-2-trimethylsilyloxytetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-77-4
chloro-trimethyl-silane

: 1-Diphenylphosphinoylheptan-3-yl benzoate

: 176242-53-8
(2R,3R,5R)-5-Butyl-3-diphenylphosphinoyl-2-phenyl-2-trimethylsilyloxytetrahydrofuran

: (2S,3S,5S)-5-Butyl-3-diphenylphosphinoyl-2-phenyl-2-trimethylsilyloxytetrahydrofuran

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; Title compound not separated from byproducts;
DOI:10.1039/a907320e

Reference yield:

: 98-88-4
benzoyl chloride

: 176242-53-8
(2R,3R,5R)-5-Butyl-3-diphenylphosphinoyl-2-phenyl-2-trimethylsilyloxytetrahydrofuran

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / Et₃N, DMAP

2: 2.) LDA / 2.) -78 degC

With dmap; triethylamine; lithium diisopropyl amide;
DOI:10.1016/0040-4039(96)00049-4

Reference yield:

: 165611-44-9
(2S,3R)-1-Diphenylphosphinoylheptane-2,3-diol

: 176242-53-8
(2R,3R,5R)-5-Butyl-3-diphenylphosphinoyl-2-phenyl-2-trimethylsilyloxytetrahydrofuran

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) SOCl₂; 2.) DBU / 1.) Et₃N

2: LiAlH₄

3: 94 percent / Et₃N, DMAP

4: 2.) LDA / 2.) -78 degC

With dmap; lithium aluminium tetrahydride; thionyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium diisopropyl amide;
DOI:10.1016/0040-4039(96)00049-4