tert-butyl (1-(3-(benzyloxy)phenyl)-2-hydroxyethyl)carbamate

Base Information

• Chemical Name: tert-butyl (1-(3-(benzyloxy)phenyl)-2-hydroxyethyl)carbamate
• CAS No.: 913523-95-2
• Molecular Formula: C₂₀H₂₅NO₄
• Molecular Weight: 343.423
• Mol file: 913523-95-2.mol

Synonyms:tert-butyl (1-(3-(benzyloxy)phenyl)-2-hydroxyethyl)carbamate

Chemical Property of tert-butyl (1-(3-(benzyloxy)phenyl)-2-hydroxyethyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of tert-butyl (1-(3-(benzyloxy)phenyl)-2-hydroxyethyl)carbamate

There total 5 articles about tert-butyl (1-(3-(benzyloxy)phenyl)-2-hydroxyethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.3%

tert-butyl (2-hydroxy-1-(3-hydroxyphenyl)ethyl)carbamate (1454273-67-6) + benzyl bromide (100-39-0) → tert-butyl (1-(3-(benzyloxy)phenyl)-2-hydroxyethyl)carbamate (913523-95-2)

Guidance literature:

With potassium carbonate; In acetone; at 20 - 60 ℃; for 20h;

Reference yield: 33.3%

tert-butyl(2-hydroxy-1-(3-hydroxyphenyl)ethyl)carbamate + benzyl bromide (100-39-0) → tert-butyl (1-(3-(benzyloxy)phenyl)-2-hydroxyethyl)carbamate (913523-95-2)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 19h;

Reference yield:

methyl amino(3-hydroxyphenyl)acetate (130697-96-0) → tert-butyl (1-(3-(benzyloxy)phenyl)-2-hydroxyethyl)carbamate (913523-95-2)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine; sodium hydrogencarbonate / methanol; dichloromethane / 21 h / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Cooling with ice

3: potassium carbonate / acetone / 20 h / 20 - 60 °C

With lithium aluminium tetrahydride; sodium hydrogencarbonate; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; acetone;

upstream raw materials:

tert-butyl (2-hydroxy-1-(3-hydroxyphenyl)ethyl)carbamate

benzyl bromide

D-α-amino-m-hydroxyphenylacetic acid

methyl amino(3-hydroxyphenyl)acetate

Downstream raw materials:

2-(3-(benzyloxy)phenyl)-2-((tert-butoxycarbonyl)amino)ethyl methanesulfonate