2-(3-(benzyloxy)phenyl)-2-((tert-butoxycarbonyl)amino)ethyl methanesulfonate

Base Information

• Chemical Name: 2-(3-(benzyloxy)phenyl)-2-((tert-butoxycarbonyl)amino)ethyl methanesulfonate
• CAS No.: 1454273-68-7
• Molecular Formula: C₂₁H₂₇NO₆S
• Molecular Weight: 421.514
• Mol file: 1454273-68-7.mol

Synonyms:2-(3-(benzyloxy)phenyl)-2-((tert-butoxycarbonyl)amino)ethyl methanesulfonate

Chemical Property of 2-(3-(benzyloxy)phenyl)-2-((tert-butoxycarbonyl)amino)ethyl methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-(benzyloxy)phenyl)-2-((tert-butoxycarbonyl)amino)ethyl methanesulfonate

There total 4 articles about 2-(3-(benzyloxy)phenyl)-2-((tert-butoxycarbonyl)amino)ethyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (1-(3-(benzyloxy)phenyl)-2-hydroxyethyl)carbamate (913523-95-2) + methanesulfonyl chloride (124-63-0) → 2-(3-(benzyloxy)phenyl)-2-((tert-butoxycarbonyl)amino)ethyl methanesulfonate (1454273-68-7)

Guidance literature:

With triethylamine; In dichloromethane;

Reference yield:

methyl amino(3-hydroxyphenyl)acetate (130697-96-0) → 2-(3-(benzyloxy)phenyl)-2-((tert-butoxycarbonyl)amino)ethyl methanesulfonate (1454273-68-7)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine; sodium hydrogencarbonate / methanol; dichloromethane / 21 h / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Cooling with ice

3: potassium carbonate / acetone / 20 h / 20 - 60 °C

4: triethylamine / dichloromethane

With lithium aluminium tetrahydride; sodium hydrogencarbonate; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; acetone;

Reference yield:

methyl 2-((tert-butoxycarbonyl)amino)-2-(3-hydroxyphenyl)acetate (526217-60-7) → 2-(3-(benzyloxy)phenyl)-2-((tert-butoxycarbonyl)amino)ethyl methanesulfonate (1454273-68-7)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Cooling with ice

2: potassium carbonate / acetone / 20 h / 20 - 60 °C

3: triethylamine / dichloromethane

With lithium aluminium tetrahydride; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; acetone;

upstream raw materials:

tert-butyl (1-(3-(benzyloxy)phenyl)-2-hydroxyethyl)carbamate

methanesulfonyl chloride

D-α-amino-m-hydroxyphenylacetic acid

methyl amino(3-hydroxyphenyl)acetate