2,2,5-trimethyl-3-(1'-p-aminomethylphenylethoxy)-4-phenyl-3-azahexane

Base Information

• Chemical Name: 2,2,5-trimethyl-3-(1'-p-aminomethylphenylethoxy)-4-phenyl-3-azahexane
• CAS No.: 293328-23-1
• Molecular Formula: C₂₃H₃₄N₂O
• Molecular Weight: 354.536
• Mol file: 293328-23-1.mol

Synonyms:2,2,5-trimethyl-3-(1'-p-aminomethylphenylethoxy)-4-phenyl-3-azahexane

Chemical Property of 2,2,5-trimethyl-3-(1'-p-aminomethylphenylethoxy)-4-phenyl-3-azahexane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2,5-trimethyl-3-(1'-p-aminomethylphenylethoxy)-4-phenyl-3-azahexane

There total 2 articles about 2,2,5-trimethyl-3-(1'-p-aminomethylphenylethoxy)-4-phenyl-3-azahexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

O-(1-(4-(azidomethyl)phenyl)ethyl)-N-(tert-butyl)-N-(2-methyl-1-phenylpropyl)hydroxylamine (393110-71-9) → 2,2,5-trimethyl-3-(1'-p-aminomethylphenylethoxy)-4-phenyl-3-azahexane (293328-23-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 16h;

DOI:10.1021/ja028392s

Reference yield:

N-tert-butyl-O-[1-(4-chloromethyl-phenyl)-ethyl]-N-(2-methyl-1-phenyl-propyl)-hydroxylamine (227000-85-3) → 2,2,5-trimethyl-3-(1'-p-aminomethylphenylethoxy)-4-phenyl-3-azahexane (293328-23-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 83.4 percent / NaN₃; 18-crown-6 / dimethylsulfoxide / 16 h / 60 °C

2: 91 percent / LiAlH₄ / tetrahydrofuran / 16 h

With lithium aluminium tetrahydride; sodium azide; 18-crown-6 ether; In tetrahydrofuran; dimethyl sulfoxide;

DOI:10.1021/ja028392s

upstream raw materials:

O-(1-(4-(azidomethyl)phenyl)ethyl)-N-(tert-butyl)-N-(2-methyl-1-phenylpropyl)hydroxylamine

N-tert-butyl-O-[1-(4-chloromethyl-phenyl)-ethyl]-N-(2-methyl-1-phenyl-propyl)-hydroxylamine