(R)-1-[{(1'-Benzyloxycarbonyl)aziridin-2'-yl}carbonyl]-3,5-dimethyl-1H-pyrazole

Base Information

• Chemical Name: (R)-1-[{(1'-Benzyloxycarbonyl)aziridin-2'-yl}carbonyl]-3,5-dimethyl-1H-pyrazole
• CAS No.: 1103830-29-0
• Molecular Formula: C₁₆H₁₇N₃O₃
• Molecular Weight: 299.329

Synonyms:(R)-1-[{(1'-Benzyloxycarbonyl)aziridin-2'-yl}carbonyl]-3,5-dimethyl-1H-pyrazole

Chemical Property of (R)-1-[{(1'-Benzyloxycarbonyl)aziridin-2'-yl}carbonyl]-3,5-dimethyl-1H-pyrazole

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Technology Process of (R)-1-[{(1'-Benzyloxycarbonyl)aziridin-2'-yl}carbonyl]-3,5-dimethyl-1H-pyrazole

There total 2 articles about (R)-1-[{(1'-Benzyloxycarbonyl)aziridin-2'-yl}carbonyl]-3,5-dimethyl-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sodium [(benzyloxy)carbonyl]chloroamide (91174-01-5) + 1-(3,5-dimethyl-1H-pyrazol-1-yl)prop-2-en-1-one (25832-37-5) → (R)-1-[{(1'-Benzyloxycarbonyl)aziridin-2'-yl}carbonyl]-3,5-dimethyl-1H-pyrazole (1103830-29-0) + (S)-1-[{(1'-Benzyloxycarbonyl)aziridin-2'-yl}carbonyl]-3,5-dimethyl-1H-pyrazole (1103830-27-8)

Guidance literature:

With Br^(1-)*C₃₇H₃₇N₂O⁽¹⁺⁾; In dichloromethane; at 20 ℃; for 6h; optical yield given as %ee;

DOI:10.1039/b812978a

Reference yield:

Br(1-)*C37H37N2O(1+) + acryloyl-1,3-oxazolidin-2-one (2043-21-2) → (R)-1-[{(1'-Benzyloxycarbonyl)aziridin-2'-yl}carbonyl]-3,5-dimethyl-1H-pyrazole (1103830-29-0) + (S)-1-[{(1'-Benzyloxycarbonyl)aziridin-2'-yl}carbonyl]-3,5-dimethyl-1H-pyrazole (1103830-27-8)

Guidance literature:

With Br^(1-)*C₃₇H₃₇N₂O⁽¹⁺⁾; In dichloromethane; at -20 ℃; for 72h; optical yield given as %ee;

DOI:10.1039/b812978a

Reference yield: 72.0%

methanol (67-56-1) + (R)-1-[{(1'-Benzyloxycarbonyl)aziridin-2'-yl}carbonyl]-3,5-dimethyl-1H-pyrazole (1103830-29-0) → O1-benzyl-O2-methyl-(2R)-aziridine-1,2-dicarboxylate (154632-86-7)

Guidance literature:

With dmap; at 20 ℃; for 2h;

DOI:10.1039/b812978a

upstream raw materials:

acryloyl-1,3-oxazolidin-2-one

sodium [(benzyloxy)carbonyl]chloroamide

1-(3,5-dimethyl-1H-pyrazol-1-yl)prop-2-en-1-one

Downstream raw materials:

O₁-benzyl-O₂-methyl-(2R)-aziridine-1,2-dicarboxylate

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