1-[5-(4-bromophenyl)-2-methylthien-3-yl]-2-(2-methyl-5-phenylthien-3-yl)cyclopentene

Base Information

• Chemical Name: 1-[5-(4-bromophenyl)-2-methylthien-3-yl]-2-(2-methyl-5-phenylthien-3-yl)cyclopentene
• CAS No.: 880088-25-5
• Molecular Formula: C₂₇H₂₃BrS₂
• Molecular Weight: 491.516
• Mol file: 880088-25-5.mol

Synonyms:1-[5-(4-bromophenyl)-2-methylthien-3-yl]-2-(2-methyl-5-phenylthien-3-yl)cyclopentene

Chemical Property of 1-[5-(4-bromophenyl)-2-methylthien-3-yl]-2-(2-methyl-5-phenylthien-3-yl)cyclopentene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[5-(4-bromophenyl)-2-methylthien-3-yl]-2-(2-methyl-5-phenylthien-3-yl)cyclopentene

There total 3 articles about 1-[5-(4-bromophenyl)-2-methylthien-3-yl]-2-(2-methyl-5-phenylthien-3-yl)cyclopentene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

3-(2-(5-chloro-2-methylthiophene-3-yl)cyclopent-1-enyl)-5-phenyl-2-methylthiophene (391895-16-2) + 1,4-bromoiodobenzene (589-87-7) → 1-[5-(4-bromophenyl)-2-methylthien-3-yl]-2-(2-methyl-5-phenylthien-3-yl)cyclopentene (880088-25-5)

Guidance literature:

3-(2-(5-chloro-2-methylthiophene-3-yl)cyclopent-1-enyl)-5-phenyl-2-methylthiophene; With tert.-butyl lithium; In tetrahydrofuran; pentane; for 1h;

With boric acid tributyl ester; In tetrahydrofuran; pentane; for 1h;

1,4-bromoiodobenzene; With sodium carbonate; ethylene glycol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; pentane; Further stages.; Heating;

DOI:10.1039/b609119a

Reference yield:

bromobenzene (108-86-1,52753-63-6) → 1-[5-(4-bromophenyl)-2-methylthien-3-yl]-2-(2-methyl-5-phenylthien-3-yl)cyclopentene (880088-25-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane

1.2: B(OBu)3 / tetrahydrofuran; hexane

1.3: 77 percent / Pd(PPh₃)4; Na₂CO₃ / tetrahydrofuran; hexane / Heating

2.1: n-BuLi / tetrahydrofuran; hexane

2.2: B(OBu)3 / tetrahydrofuran; hexane

2.3: 76 percent / Pd(PPh₃)4; Na₂CO₃ / tetrahydrofuran; hexane / Heating

With n-butyllithium; In tetrahydrofuran; hexane;

DOI:10.1080/15421400590946398

Reference yield:

1,2-bis(5-chloro-2-methylthien-3-yl)cyclopent-1-ene (219537-97-0) → 1-[5-(4-bromophenyl)-2-methylthien-3-yl]-2-(2-methyl-5-phenylthien-3-yl)cyclopentene (880088-25-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane

1.2: B(OBu)3 / tetrahydrofuran; hexane

1.3: 77 percent / Pd(PPh₃)4; Na₂CO₃ / tetrahydrofuran; hexane / Heating

2.1: n-BuLi / tetrahydrofuran; hexane

2.2: B(OBu)3 / tetrahydrofuran; hexane

2.3: 76 percent / Pd(PPh₃)4; Na₂CO₃ / tetrahydrofuran; hexane / Heating

With n-butyllithium; In tetrahydrofuran; hexane;

DOI:10.1080/15421400590946398

upstream raw materials:

bromobenzene

1,2-bis(5-chloro-2-methylthien-3-yl)cyclopent-1-ene

3-(2-(5-chloro-2-methylthiophene-3-yl)cyclopent-1-enyl)-5-phenyl-2-methylthiophene

1,4-bromoiodobenzene